ArticleCell2024
Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity.
Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 101 citations in OpenAlex.
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- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Metabolite-mediated plant immunity: From traditional defenders to artificial elicitors.Journal of integrative plant biology · 2026Review
- Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation.Journal of integrative plant biology · 2026Review
- Allelic variation of an LRR only protein confers dual pathogen resistance in Arabidopsis.Nature communications · 2026Article
- A Virus-Inducible E3-RLCK-MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- PSKR1-mediated phosphorylation of βCA2 activates its carbonic anhydrase activity to integrate COPlant communications · 2026Article
- MdRLKT1-MdRAX2-MdMKS1 Module Positively Regulating Resistance to Cytospora mali in Apple.Plant biotechnology journal · 2026Article
- Coordination of PTI and ETI in legume-rhizobium mutualism.aBIOTECH · 2026Review
- Rice false smut fungus hijacks rice lipid signalling to manipulate floret development and immunity.Nature plants · 2026Article
- De-repression of protein phosphatase 5 by the chaperone organizer HOP1 activates plant NLR immunity.Nature plants · 2026Article
- Motif-based substrate mapping of the receptor-like cytoplasmic kinase BIK1 reveals novel components and regulatory nodes of plant immunity.Nature plants · 2026Article
- New alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions.Nature plants · 2026Article
- The diverse roles of host membranes in plant-microbe interactions.PLoS pathogens · 2026Article
- Rice phospholipase C4 enhances CaPlant communications · 2026Article
- Phosphatidic Acid Application to Enhance Plant Virus Resistance.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Genome-Wide Identification of the AGC Kinase Family in Tetraploid Potato (Plants (Basel, Switzerland) · 2025Article
- CDP-DAG synthases regulate plant growth and broad-spectrum disease resistance.Plant signaling & behavior · 2025Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Phosphatidic acid (PA) and reactive oxygen species (ROS) are crucial cellular messengers mediating diverse signaling processes in metazoans and plants. How PA homeostasis is tightly regulated and intertwined with ROS signaling upon immune elicitation remains elusive. We report here that Arabidopsis diacylglycerol kinase 5 (DGK5) regulates plant pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). The pattern recognition receptor (PRR)-associated kinase BIK1 phosphorylates DGK5 at Ser-506, leading to a rapid PA burst and activation of plant immunity, whereas PRR-activated intracellular MPK4 phosphorylates DGK5 at Thr-446, which subsequently suppresses DGK5 activity and PA production, resulting in attenuated plant immunity. PA binds and stabilizes the NADPH oxidase RESPIRATORY BURST OXIDASE HOMOLOG D (RBOHD), regulating ROS production in plant PTI and ETI, and their potentiation. Our data indicate that distinct phosphorylation of DGK5 by PRR-activated BIK1 and MPK4 balances the homeostasis of cellular PA burst that regulates ROS generation in coordinating two branches of plant immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.