Evidence map›Paper›PMID 38244276›Full record

ArticleCurrent research in translational medicine2024

Adjusting diffusing capacity for anemia in patients undergoing allogeneic HCT: a comparison of two methodologies.

Hemang Yadav, Mehrdad Hefazi Torghabeh, Sumedh S Hoskote, Kelly M Pennington, Kaiser G Lim, Paul D Scanlon, Alexander S Niven, William J Hogan

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hemang YadavDivision of Pulmonary and Critical Care Medicine, Pulmonary Function Laboratory, Mayo Clinic, Rochester, United States. Electronic address: yadav.hemang@mayo.edu.
Mehrdad Hefazi TorghabehDivision of Pulmonary and Critical Care Medicine, William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, United States.
Sumedh S HoskoteDivision of Pulmonary and Critical Care Medicine, Pulmonary Function Laboratory, Mayo Clinic, Rochester, United States.
Kelly M PenningtonDivision of Hematology, William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, United States.
Kaiser G LimDivision of Pulmonary and Critical Care Medicine, Pulmonary Function Laboratory, Mayo Clinic, Rochester, United States.
Paul D ScanlonDivision of Pulmonary and Critical Care Medicine, Pulmonary Function Laboratory, Mayo Clinic, Rochester, United States.
Alexander S NivenDivision of Pulmonary and Critical Care Medicine, Pulmonary Function Laboratory, Mayo Clinic, Rochester, United States.
William J HoganDivision of Pulmonary and Critical Care Medicine, William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, United States.
Mayo Clinic in Florida · USMayo Clinic · USMayo Clinic in Arizona · US

Funding

Predicting and Preventing Acute Respiratory Distress Syndrome after Hematopoietic Stem Cell TransplantationK23HL151671 · NHLBI · MAYO CLINIC ROCHESTER · PI YADAV, HEMANG · 2021 to 2025
$813k
NHLBI NIH HHS K23 HL151671
6 · The paper itself

Abstract

backgroundDiffusing capacity (DLCO) measurements are affected by hemoglobin. Two adjustment equations are used: Cotes (recommended by ATS/ERS) and Dinakara (used in the hematopoietic stem cell transplantation comorbidity index [HCT-CI]). It is unknown how these methods compare, and which is better from a prognostication standpoint. STUDY

designThis is a retrospective cohort of 1273 adult patients who underwent allogeneic HCT, completed a pre-transplant DLCO and had a concurrent hemoglobin measurement. Non-relapse mortality was measured using competing risk analysis.

resultsPatients had normal spirometry (FEV

conclusionThe ERS/ATS recommended Cotes method likely underestimates DLCO in patients with anemia, whereas the Dinakara (used in the HCT-CI score) overestimates DLCO. The Cotes method is superior to the Dinakara method score in predicting overall survival and relapse-free survival in patients undergoing allogeneic HCT.

Indexed as

AnemiaHematopoietic Stem Cell TransplantationPulmonary Diffusing CapacityTransplantation, HomologousAdultAgedFemaleHemoglobinsHumansMaleMiddle AgedPrognosisRetrospective StudiesHemoglobinsAnemiaBone marrow transplantDiffusing capacityDLCOHCT

Identifiers

PMID38244276
PMCPMC11102530
OpenAlexW4388805854

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.