Evidence map›Paper›PMID 38244050›Full record

ArticleAnalytical and bioanalytical chemistry2024

Study of metalation of thioredoxin by gold(I) therapeutic compounds using combined liquid chromatography/capillary electrophoresis with inductively coupled plasma/electrospray MS/MS detection.

Mikel Bernabeu De Maria, Magdalena Matczuk, Diego Tesauro, Michele Saviano, Jacek Sikorski, Giovanni Chiappetta, Simon Godin, Joanna Szpunar, Ryszard Lobinski, Luisa Ronga

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mikel Bernabeu De MariaUniversité de Pau Et Des Pays de L'Adour, E2S UPPA, CNRS, Institute of Analytical and Physical Chemistry for the Environment and Materials (IPREM-UMR 5254), 64053, Pau, France.
Magdalena MatczukFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664, Warsaw, Poland.
Diego TesauroDepartment of Pharmacy and CIRPeB, Università degli Studi di Napoli Federico II, Via Montesano 49, 80131, Naples, Italy.
Michele SavianoInstituto Di Cristallografia (IC), CNR, 70126, Caserta, Italy.
Jacek SikorskiFaculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664, Warsaw, Poland.
Giovanni ChiappettaBiological Mass Spectrometry and Proteomics (SMBP), ESPCI Paris, Université PSL, LPC CNRS UMR8249, 75005, Paris, France.
Simon GodinUniversité de Pau Et Des Pays de L'Adour, E2S UPPA, CNRS, Institute of Analytical and Physical Chemistry for the Environment and Materials (IPREM-UMR 5254), 64053, Pau, France.
Joanna SzpunarUniversité de Pau Et Des Pays de L'Adour, E2S UPPA, CNRS, Institute of Analytical and Physical Chemistry for the Environment and Materials (IPREM-UMR 5254), 64053, Pau, France.
Ryszard LobinskiUniversité de Pau Et Des Pays de L'Adour, E2S UPPA, CNRS, Institute of Analytical and Physical Chemistry for the Environment and Materials (IPREM-UMR 5254), 64053, Pau, France.
Luisa RongaUniversité de Pau Et Des Pays de L'Adour, E2S UPPA, CNRS, Institute of Analytical and Physical Chemistry for the Environment and Materials (IPREM-UMR 5254), 64053, Pau, France. luisa.ronga@univ-pau.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The reactivity of thioredoxin (Trx1) with the Au(I) drug auranofin (AF) and two therapeutic N-heterocyclic carbene (NHC)

Indexed as

GoldTandem Mass SpectrometryAuranofinChromatography, LiquidElectrophoresis, CapillaryGold CompoundsImmunologic FactorsSpectrometry, Mass, Electrospray IonizationThioredoxinsAuranofinGoldGold CompoundsImmunologic FactorsThioredoxinsAu(I) complexesESI–MSICP-MSMetal-binding siteMetal-protein adductsTrx

Identifiers

PMID38244050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.