Evidence map›Paper›PMID 38244041›Full record

ArticleEuropean journal of pediatrics2024

The risk of hospitalisation from RSV is not increased by co-infection in children under 24-months-of-age.

Alessandra Chiara Francesca Ferrari, Elisa Giani, Andrea Enzo Scaramuzza, Vera Cutuli, Martina Giambarda, Francesca Rota, Cecilia Verderio, Leonardo Cimardi, Gloria Fumagalli, Martina Soliani and 3 more

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Article in European journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Alessandra Chiara Francesca FerrariDepartment of Paediatrics, ASST Cremona, Maggiore Hospital, Ospedale Maggiore, Viale Concordia 1, 26100, Cremona, Italy.
Elisa GianiDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Andrea Enzo ScaramuzzaDepartment of Paediatrics, ASST Cremona, Maggiore Hospital, Ospedale Maggiore, Viale Concordia 1, 26100, Cremona, Italy. a.scaramuzza@gmail.com.
Vera CutuliPostgraduate School of Paediatrics, University of Brescia, Brescia, Italy.
Martina GiambardaPostgraduate School of Paediatrics, University of Brescia, Brescia, Italy.
Francesca RotaPostgraduate School of Paediatrics, University of Brescia, Brescia, Italy.
Cecilia VerderioPostgraduate School of Paediatrics, University of Brescia, Brescia, Italy.
Leonardo CimardiDepartment of Laboratory Medicine-Haemostasis and Thrombosis Centre, ASST Cremona, Maggiore Hospital, Cremona, Italy.
Gloria FumagalliDepartment of Paediatrics, ASST Cremona, Maggiore Hospital, Ospedale Maggiore, Viale Concordia 1, 26100, Cremona, Italy.
Martina SolianiDepartment of Paediatrics, ASST Cremona, Maggiore Hospital, Ospedale Maggiore, Viale Concordia 1, 26100, Cremona, Italy.
Bruno Angelo DreraDepartment of Neonatal Intensive Care Unit, ASST Cremona, Maggiore Hospital, Cremona, Italy.
Sophie TestaDepartment of Laboratory Medicine-Haemostasis and Thrombosis Centre, ASST Cremona, Maggiore Hospital, Cremona, Italy.
Claudio CavalliDepartment of Paediatrics, ASST Cremona, Maggiore Hospital, Ospedale Maggiore, Viale Concordia 1, 26100, Cremona, Italy.
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Brescia · ITAzienda Socio Sanitaria Territoriale di CremonaHumanitas University · ITOspedale Maggiore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent pandemic prompted renewed interest in paediatric respiratory infections, including whether co-infections - particularly with RSV - have an adverse prognostic impact. We evaluated the charts of all children presenting with respiratory symptoms to our unit between October 2022 and April 2023, each of whom was subjected to a multiplex PCR assay to detect eight viral targets and one bacterial target and examine the relationships between mono- and co-infections and hospitalization outcomes. We observed that younger age and RSV infection were both associated with the need for hospitalisation and the duration of hospitalisation after adjusting for confounders. Co-infection was, however, not associated with these outcomes.   Conclusion: This real-world data add to a growing consensus that RSV increases the risk of hospitalisation, while other co-infections, except for co-infection with SARS-CoV-2, do not. Given the timeframe over which our study was conducted, only a few children had SARS-CoV-2 co-infection, so we could not confirm any significant effect from this interaction. What is Known: • RSV increases the risk of hospitalisation and the need tor ventilatory support, especially in very young children. What is New: • Younger age and RSV infection were both associated with the need for hospitalisation and the duration of hospitalisation after adjusting for confounders. • Co-infection was, however, not associated with these outcomes.

Indexed as

CoinfectionRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsChildChild, PreschoolHospitalizationHumansInfantRisk Factors

Identifiers

PMID38244041
OpenAlexW4391052059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.