Evidence map›Paper›PMID 38243945›Full record

ArticleMini reviews in medicinal chemistry2024

An

Pablo Rayff da Silva, Natalia Diniz Nunes Pazos, Jéssica Cabral de Andrade, Natália Ferreira de Sousa, Hugo Fernandes Oliveira Pires, Jaislânia Lucena de Figueiredo Lima, Arthur Lins Dias, Mirian Graciela da Silva Stiebbe Salvadori, Adriana Maria Fernandes de Oliveira Golzio, Ricardo Dias de Castro and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Mini reviews in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pablo Rayff da SilvaPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Natalia Diniz Nunes PazosPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Jéssica Cabral de AndradePsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Natália Ferreira de SousaCheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-900, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Hugo Fernandes Oliveira PiresPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Jaislânia Lucena de Figueiredo LimaPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Arthur Lins DiasPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Mirian Graciela da Silva Stiebbe SalvadoriPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Adriana Maria Fernandes de Oliveira GolzioPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Ricardo Dias de CastroPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Marcus T ScottiCheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-900, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Vaishali M PatilKIET School of Pharmacy, KIET Group of Institutions, Ghaziabad 201206, Uttar Pradesh, India.
Cícero Francisco Bezerra FelipePsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Reinaldo Nóbrega de AlmeidaPsychopharmacology Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051- 085, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.
Luciana ScottiCheminformatics Laboratory, Institute of Drugs and Medicines Research, Federal University of Paraíba, 58051-900, Via Ipê Amarelo, S/N, João Pessoa, Paraíba, Brazil.ORCID 0000-0003-1866-4107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain is characterized by the unpleasant sensory and emotional sensation associated with actual or potential tissue damage, whereas nociception refers to the mechanism by which noxious stimuli are transmitted from the periphery to the CNS. The main drugs used to treat pain are nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics, which have side effects that limit their use. Therefore, in the search for new drugs with potential antinociceptive effects, essential oils have been studied, whose constituents (monoterpenes) are emerging as a new therapeutic possibility. Among them, linalool and its metabolites stand out. The present study aims to investigate the antinociceptive potential of linalool and its metabolites through a screening using an

Indexed as

Acyclic MonoterpenesAnalgesicsMolecular Docking SimulationAnimalsComputer SimulationHumansMonoterpenesPainAcyclic MonoterpenesAnalgesicslinaloolMonoterpenesenzymes.essential oilsmolecular dockingMonoterpenesnociceptiontetrahydrolinalool

Identifiers

PMID38243945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.