Evidence map›Paper›PMID 38243878›Full record

ArticleAdvanced biology2024

Hydrogel Alginate Considerations for Improved 3D Matrix Stability and Cell Graft Viability and Function in Studying Type 1 Diabetes In Vitro.

Victor M Quiroz, Yuanjia Wang, Amanda I Rakoski, Devi Kasinathan, Sarah Y Neshat, Jennifer Hollister-Lock, Joshua C Doloff

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Victor M QuirozDepartment of Biomedical Engineering, Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0003-0819-368X
Yuanjia WangDepartment of Biomedical Engineering, Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Amanda I RakoskiDepartment of Biomedical Engineering, Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0002-0855-7124
Devi KasinathanDepartment of Physiology, Johns Hopkins University, Baltimore, MD, 21205, USA.ORCID 0000-0001-7653-0380
Sarah Y NeshatDepartment of Biomedical Engineering, Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0001-7849-5603
Jennifer Hollister-LockSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA, 02215, USA.
Joshua C DoloffDepartment of Biomedical Engineering, Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.ORCID 0000-0002-4323-3264
Johns Hopkins University · USBloomberg (United States) · USJoslin Diabetes Center · US

Funding

HopkinsPREP: Research, Community, Professional Training and Personal GrowthR25GM109441 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WILSON, KATHERINE L · 2015 to 2024
$3.2M
Juvenile Diabetes Research Foundation (JDRF) 1-PNF-2019-782-S-BJuvenile Diabetes Research Foundation (JDRF) 2-SRA-2022-1253-S-BNational Institute of Health Post Baccalaureate Research Education Program R25GM109441National Science Foundation DGE-1746891NIGMS NIH HHS R25 GM109441
6 · The paper itself

Abstract

Biomedical devices such as islet-encapsulating systems are used for treatment of type 1 diabetes (T1D). Despite recent strides in preventing biomaterial fibrosis, challenges remain for biomaterial scaffolds due to limitations on cells contained within. The study demonstrates that proliferation and function of insulinoma (INS-1) cells as well as pancreatic rat islets may be improved in alginate hydrogels with optimized gel%, crosslinking, and stiffness. Quantitative polymerase chain reaction (qPCR)-based graft phenotyping of encapsulated INS-1 cells and pancreatic islets identified a hydrogel stiffness range between 600 and 1000 Pa that improved insulin Ins and Pdx1 gene expression as well as glucose-sensitive insulin-secretion. Barium chloride (BaCl

Indexed as

AlginatesCell SurvivalDiabetes Mellitus, Type 1HydrogelsAnimalsBarium CompoundsCell Line, TumorChloridesInsulinIslets of LangerhansIslets of Langerhans TransplantationRatsTissue ScaffoldsAlginatesbarium chlorideBarium CompoundsChloridesHydrogelsInsulin3D culturealginate cell encapsulationmaterial characterizationmicrophysiological systemstype 1 diabetes cell therapy

Identifiers

PMID38243878
PMCPMC11259579
OpenAlexW4391051333

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.