Evidence map›Paper›PMID 38243826›Full record

ReviewEuropean journal of preventive cardiology2024

Obesity and cardiovascular health.

Aimee Welsh, Muhammad Hammad, Ileana L Piña, Jacquelyn Kulinski

Open access · hybridAbstract readReview
In one paragraph

Review in European journal of preventive cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 2 pooled it
71.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. DEFINE: A Prospective, Randomized, Phase 4 Trial to Assess a Protease Inhibitor-Based Regimen Switch Strategy to Manage Integrase Inhibitor-Related Weight Gain.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Trial
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Article
  12. Weight discrimination and metabolic syndrome: Examining discrimination attributions and frequency across settings.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
  13. Article
  14. Article
  15. Review
  16. Observational
  17. Article
  18. Review
  19. Article
  20. Review

63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Aimee WelshDivision of Cardiology, Medical College of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI 53226, USA.
Muhammad HammadDivision of Cardiology, Medical College of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI 53226, USA.ORCID 0000-0003-3735-9060
Ileana L PiñaDivision of Cardiology, Thomas Jefferson University, 925 Chestnut Street, Philadelphia, PA 19107, USA.
Jacquelyn KulinskiDivision of Cardiology, Medical College of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI 53226, USA.ORCID 0000-0002-1517-7197
Medical College of Wisconsin · USThomas Jefferson University · US

Funding

Stand Up for Your Health: A Randomized StudyR01HL162888 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Jacquelyn P Kulinski · 2023 to 2026
$2.3M
NHLBI NIH HHS R01 HL162888NHLBI NIH HHS R01HL162888NIH HHS
6 · The paper itself

Abstract

Obesity has risen to epidemic levels worldwide over the past few decades and has become a huge global health burden owing to its direct contribution to the development of some of the most prevalent chronic diseases including diabetes, hypertension, hyperlipidaemia, and other cardiovascular diseases. Obesity is a disease of positive energy balance resulting from complex interactions between abnormal neurohumoral responses and an individual's socioeconomic, environmental, behavioural, and genetic factors leading to a state of chronic inflammation. Understanding the complex nature of the disease is crucial in determining the best approach to combat its rising numbers. Despite recent advancements in pharmacological therapy for the treatment of obesity, reversing weight gain and maintaining weight loss is challenging due to the relapsing nature of the disease. Prevention, therefore, remains the key which needs to start in utero and continued throughout life. This review summarizes the role obesity plays in the pathophysiology of various cardiovascular diseases both by directly affecting endothelial and myocyte function and indirectly by enhancing major cardiovascular risk factors like diabetes, hypertension, and hyperlipidaemia. We highlight the importance of a holistic approach needed to prevent and treat this debilitating disease. Particularly, we analyse the effects of plant-based diet, regular exercise, and non-exercise activity thermogenesis on obesity and overall cardiorespiratory fitness. Moreover, we discuss the significance of individualizing obesity management with a multimodal approach including lifestyle modifications, pharmacotherapy, and bariatric surgery to tackle this chronic disease.

Indexed as

Cardiovascular DiseasesObesityHeart Disease Risk FactorsHumansRisk AssessmentRisk FactorsRisk Reduction BehaviorAdiposityCardiopulmonary fitnessCardiovascular diseaseHealthy lifestyleHeart disease risk factorsHolistic healthObesityOverweight

Identifiers

PMID38243826
PMCPMC11144464
OpenAlexW4391050623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.