Evidence map›Paper›PMID 38243646›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function.

Yue Han, Xian Tong, Runqi Zhou, Yilin Wang, Yuge Chen, Liang Chen, Xinhua Hong, Linmei Wu, Zhiqiang Lin, Yichi Zhang and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 5 countries.

Yue HanInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Xian TongInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Runqi ZhouInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Yilin WangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Yuge ChenInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Liang ChenInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Xinhua HongInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Linmei WuInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Zhiqiang LinInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Yichi ZhangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Xuejia ZhangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Chaoming HuInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Bin LiInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Yifan PingInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Zelin CaoInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Zhou YeApplied Oral Sciences and Community Dental Care, Faculty of Dentistry, University of Hong Kong, Hong Kong, 999077, China.
Zhongchen SongDepartment of Periodontology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200125, China.
Yuncang LiSchool of Engineering, RMIT University, Melbourne, VIC, 3001, Australia.
Cuie WenSchool of Engineering, RMIT University, Melbourne, VIC, 3001, Australia.ORCID 0000-0001-8008-3536
Yongsheng ZhouDepartment of Prosthodontics, National Center for Stomatology, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, National Clinical Research Center for Oral Disease, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Jixing LinInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Shengbin HuangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Wenzhou Medical University · CNRMIT University · AUNational Clinical Research · USShanghai Jiao Tong University · CNUniversity of Alberta · CAUniversity of Hong Kong · HK

Funding

Medical Science and Technology Project of Zhejiang Province WKJ-ZJ-2311National Natural Science Foundation of China 82270991Natural Science Foundation of Zhejiang Province LR21H140002Opening Project of Guangxi Key Laboratory of the Rehabilitation and Reconstruction for Oral and Maxillofacial Research GXKLRROM2106Opening Research fund from Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine 2022SKLS-KFKT011Science and Technology Plan Project of Wenzhou Municipality ZY2021015Zhejiang Xinmiao Talents Program 2021R413083
6 · The paper itself

Abstract

Zinc (Zn)-dysprosium (Dy) binary alloys are promising biodegradable bone fracture fixation implants owing to their attractive biodegradability and mechanical properties. However, their clinical application is a challenge for bone fracture healing, due to the lack of Zn-Dy alloys with tailored proper bio-mechanical and osteointegration properties for bone regeneration. A Zn-5Dy alloy with high strength and ductility and a degradation rate aligned with the bone remodeling cycle is developed. Here, mechanical stability is further confirmed, proving that Zn-5Dy alloy can resist aging in the degradation process, thus meeting the mechanical requirements of fracture fixation. In vitro cellular experiments reveal that the Zn-5Dy alloy enhances osteogenesis and angiogenesis by elevating SIRT4-mediated mitochondrial function. In vivo Micro-CT, SEM-EDS, and immunohistochemistry analyses further indicate good biosafety, suitable biodegradation rate, and great osteointegration of Zn-5Dy alloy during bone healing, which also depends on the upregulation of SIRT4-mediated mitochondrial events. Overall, the study is the first to report a Zn-5Dy alloy that exerts remarkable osteointegration properties and has a strong potential to promote bone healing. Furthermore, the results highlight the importance of mitochondrial modulation and shall guide the future development of mitochondria-targeting materials in enhancing bone fracture healing.

Indexed as

AlloysOsteogenesisAbsorbable ImplantsDysprosiumFractures, BoneHumansMaterials TestingMitochondriaMitochondrial ProteinsSirtuinsZincAlloysDysprosiumMitochondrial ProteinsSIRT4 protein, humanSirtuinsZincbiodegradable zinc alloybone fractureosteointegrationrare earth dysprosium (Dy)SIRT4

Identifiers

PMID38243646
PMCPMC10987155
OpenAlexW4391052797

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.