ArticleMolecular therapy : the journal of the American Society of Gene Therapy2024
Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss.
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Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Compensatory Interplay Between Clarin-1 and Clarin-2 Deafness-Associated Proteins Governs Phenotypic Variability in Hearing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms.Nature communications · 2026Article
- Gene supplementation with precise transgene expression rescues hearing loss in a mouse model with an Mpzl2 East Asian founder variant.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Dual AAV gene therapy achieves recovery of hearing and auditory processing in a DFNB16 mouse model.Clinical and translational medicine · 2026Article
- Antisense oligonucleotide therapy mitigates autosomal dominant progressive hearing loss in a murine model of human DFNA2.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Recent preclinical and clinical advances in gene therapy for hereditary hearing loss.Molecules and cells · 2025Review
- IsMedComm · 2025Article
- AIMP1 exerts hearing protection role in age related hearing loss mice by regulating SIRT1 expression.BMC geriatrics · 2025Article
- Immunoinformatic development of a multiepitope messenger RNA vaccine targeting lipoate protein ligase and dihydrolipoamide dehydrogenase proteins ofVeterinary world · 2025Article
- Advancing precision ear medicine: leveraging animal models for disease insights and therapeutic innovations.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice.Nature aging · 2025Article
- Cell tropism of adeno-associated viruses within the mouse inner ear in vivo: from embryonic to adult stages.Scientific reports · 2025Article
- Accelerated Hydration Site Localization and Thermodynamic Profiling.Journal of chemical information and modeling · 2025Article
- Inner Ear Gene Therapy: An Overview from Bench to Bedside.Molecular diagnosis & therapy · 2025Review
- Defects in hair cells disrupt the development of auditory peripheral circuitry.Nature communications · 2024Article
- Molecular signatures diversity unveiled through a comparative transcriptome analysis of longissimus dorsi and psoas major muscles in Hanwoo cattle.Animal biotechnology · 2024Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 4 countries.
Clara MendiaInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France; Sorbonne Université, Collège Doctoral, 75005 Paris, France.
Thibault PeineauInstitut de l'Audition and Université de Bordeaux, Laboratoire de Neurophysiologie de la Synapse Auditive, Bordeaux Neurocampus, 33076 Bordeaux, France.
Mina ZamaniDepartment of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran.
Chloé FelgerolleInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France.
Nawal YahiaouiInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France.
Nele ChristophersenInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany; Institute of Human Genetics, University Medical Center Göttingen, 37075 Göttingen, Germany.
Samantha PapalInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France.
Audrey MaudouxInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France.
Reza MaroofianDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, WC1E 6BT London, UK.
Pranav PatniInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France.
Sylvie NouailleInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France.
Michael R BowlUCL Ear Institute, University College London, 332 Gray's Inn Road, WC1X 8EE London, UK.
Sedigheh DelmaghaniInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France.
Hamid GalehdariDepartment of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran.
Barbara VonaInstitute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, 37075 Göttingen, Germany; Institute of Human Genetics, University Medical Center Göttingen, 37075 Göttingen, Germany.
Didier DulonInstitut de l'Audition and Université de Bordeaux, Laboratoire de Neurophysiologie de la Synapse Auditive, Bordeaux Neurocampus, 33076 Bordeaux, France.
Sandrine VitryInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France. Electronic address: sandrine.vitry@pasteur.fr.
Aziz El-AmraouiInstitut Pasteur, Université Paris Cité, INSERM AO06, Institut de l'Audition, Unit Progressive Sensory Disorders, Pathophysiology and Therapy, 63 rue de Charenton, 75012 Paris, France. Electronic address: aziz.el-amraoui@pasteur.fr.
Institut Pasteur · FRInserm · FRShahid Chamran University of Ahvaz · IRUniversité de Bordeaux · FRUniversity College London · GBUniversity of Göttingen · DEUniversité Paris Cité · FR
Funding
Medical Research Council MR/X004597/1
Abstract
Hearing loss is a major health concern affecting millions of people worldwide with currently limited treatment options. In clarin-2-deficient Clrn2
Indexed as
Hair Cells, AuditoryHearing LossAnimalsDietary SupplementsHearingHumansMiceStereociliaclarin-2gene therapyprogressive hearing loss
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LicenceCC BY-NC-ND
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.