Evidence map›Paper›PMID 38243373›Full record

ReviewFEBS letters2024

Advances in multimodal mass spectrometry for single-cell analysis and imaging enhancement.

Seth W Croslow, Timothy J Trinklein, Jonathan V Sweedler

Open access · hybridAbstract readReview
In one paragraph

Review in FEBS letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Roles of FXR in Lipid Biochemistry within Hepatocellular Carcinoma Using MALDI MSI.Journal of the American Society for Mass Spectrometry · 2026
    Article
  3. Article
  4. Article
  5. Plasma-Derived Extracellular Vesicle Proteomics.Journal of proteome research · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. A micropeptide regulates seed desiccation.Frontiers in plant science · 2025
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Seth W CroslowDepartment of Chemistry, University of Illinois at Urbana-Champaign, IL, USA.
Timothy J TrinkleinBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA.
Jonathan V SweedlerDepartment of Chemistry, University of Illinois at Urbana-Champaign, IL, USA.ORCID 0000-0003-3107-9922
University of Illinois Urbana-Champaign · US

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
Center for Sub-Cellular GenomicsRM1HG010023 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI EBERWINE, JAMES H, KIM, JUNHYONG · 2018 to 2022
$11.0M
High-Throughput 3D Multiscale Mass Spectrometry Imaging for Understanding Neurochemical Heterogeneity in Alzheimer's DiseaseR01AG078797 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Fan Lam, Orly Lazarov · 2022 to 2026
$3.6M
NHGRI NIH HHS RM1 HG010023NHGRI NIH HHS RM1HG010023NIA NIH HHS 1R01AG078797NIA NIH HHS R01 AG078797NIDA NIH HHS P30 DA018310NIDA NIH HHS P30DA018310
6 · The paper itself

Abstract

Multimodal mass spectrometry (MMS) incorporates an imaging modality with probe-based mass spectrometry (MS) to enable precise, targeted data acquisition and provide additional biological and chemical data not available by MS alone. Two categories of MMS are covered; in the first, an imaging modality guides the MS probe to target individual cells and to reduce acquisition time by automatically defining regions of interest. In the second category, imaging and MS data are coupled in the data analysis pipeline to increase the effective spatial resolution using a higher resolution imaging method, correct for tissue deformation, and incorporate fine morphological features in an MS imaging dataset. Recent methodological and computational developments are covered along with their application to single-cell and imaging analyses.

Indexed as

Single-Cell AnalysisSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationcellimagingmass spectrometrymicroscopymultimodalsegmentationsubcellular

Identifiers

PMID38243373
PMCPMC10963143
OpenAlexW4391053140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.