Evidence map›Paper›PMID 38243280›Full record

ReviewMolecular cancer2024

Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance.

Chi Zhang, Chaoying Qin, Saikat Dewanjee, Hiranmoy Bhattacharya, Pratik Chakraborty, Niraj Kumar Jha, Moumita Gangopadhyay, Saurabh Kumar Jha, Qing Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecular cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  9. Article
  10. Unlocking the potential of extracellular vesicles in cancer diagnosis and therapy: a comprehensive bibliometric study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  11. Article
  12. Article
  13. Review
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  19. Review
  20. Extracellular vesicles in spine tumors: biological roles, immune modulation, and therapeutic implications.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Chi Zhang *Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Chaoying Qin *Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Saikat DewanjeeAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, West Bengal, India. saikat.dewanjee@jadavpuruniversity.in.
Hiranmoy BhattacharyaAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, West Bengal, India.
Pratik ChakrabortyAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, West Bengal, India.
Niraj Kumar JhaCentre of Research Impact and Outreach, Chitkara University Institute of Engineering and Technology, Chitkara University, Punjab, India.
Moumita GangopadhyayDepartment of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat, Kolkata, 700126, West Bengal, India.
Saurabh Kumar JhaDepartment of Zoology, Kalindi College, University of Delhi, New Delhi, Delhi, 110008, India. jhasaurabh017@gmail.com.
Qing LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, 410008, China. liuqingdr@csu.edu.cn.
Jadavpur University · INXiangya Hospital Central South University · CNAdamas University · INChitkara University · INUniversity of Delhi · IN

Funding

National Key Research and Development Program of China 2022YFE0133400Natural Science Foundation of China 82202440, 82203600, 82172834
6 · The paper itself

Abstract

The production and release of tumor-derived small extracellular vesicles (TDSEVs) from cancerous cells play a pivotal role in the propagation of cancer, through genetic and biological communication with healthy cells. TDSEVs are known to orchestrate the invasion-metastasis cascade via diverse pathways. Regulation of early metastasis processes, pre-metastatic niche formation, immune system regulation, angiogenesis initiation, extracellular matrix (ECM) remodeling, immune modulation, and epithelial-mesenchymal transition (EMT) are among the pathways regulated by TDSEVs. MicroRNAs (miRs) carried within TDSEVs play a pivotal role as a double-edged sword and can either promote metastasis or inhibit cancer progression. TDSEVs can serve as excellent markers for early detection of tumors, and tumor metastases. From a therapeutic point of view, the risk of cancer metastasis may be reduced by limiting the production of TDSEVs from tumor cells. On the other hand, TDSEVs represent a promising approach for in vivo delivery of therapeutic cargo to tumor cells. The present review article discusses the recent developments and the current views of TDSEVs in the field of cancer research and clinical applications.

Indexed as

Extracellular VesiclesMicroRNAsNeoplasmsCell CommunicationClinical RelevanceEpithelial-Mesenchymal TransitionHumansNeoplasm MetastasisTumor MicroenvironmentMicroRNAsBiomarkersCancerEpithelial-mesenchymal transitionMetastasisMicroRNAOncogenic transformationTumor-derived small extracellular vesiclesTumor microenvironment

Identifiers

PMID38243280
PMCPMC10797874
OpenAlexW4391033130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.