Evidence map›Paper›PMID 38243094›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2024

Perioperative copeptin: predictive value and risk stratification in patients undergoing major noncardiac surgery-a prospective observational cohort study.

Firmin Kamber, Sebastian Roth, Daniel Bolliger, Esther Seeberger, Johannes Nienhaus, Christian Mueller, Giovanna Lurati Buse, Eckhard Mauermann

Registry-linked trialOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02687776 (Perioperative Copeptin), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02687776 completednot on this map

Perioperative Copeptin: Predictive Value and Risk Stratification in Patients Undergoing Major Surgery

TypeobservationalSponsorUniversity Hospital, Basel, SwitzerlandRan2016 to 2021Enrolled517ConditionsPerioperative Myocardial Injury
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Advances in biomarkers for myocardial injury after non-cardiac surgery.Journal of anesthesia and translational medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Firmin KamberAnesthesiology Clinic, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland. firmin.kamber@usb.ch.ORCID 0000-0003-4405-6420
Sebastian RothUniversity of Anesthesiology, University Hospital Dusseldorf, Düsseldorf, Germany.
Daniel BolligerAnesthesiology Clinic, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Esther SeebergerAnesthesiology Clinic, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Johannes NienhausUniversity of Anesthesiology, University Hospital Dusseldorf, Düsseldorf, Germany.
Christian MuellerDepartment of Cardiology, University Hospital Basel, Basel, Switzerland.
Giovanna Lurati BuseUniversity of Anesthesiology, University Hospital Dusseldorf, Düsseldorf, Germany.
Eckhard MauermannFaculty of Medicine, University of Basel, Basel, Switzerland.
Düsseldorf University Hospital · DEUniversity Hospital of Basel · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBiomarkers can aid in perioperative risk stratification. While preoperative copeptin has been associated with adverse events, intraoperative information is lacking and this association may rather reflect a baseline risk. Knowledge about correlations between postoperative copeptin measurements and clinically relevant outcomes is scarce. We examined the association of perioperative copeptin concentrations with postoperative all-cause mortality and/or major adverse cardiac and cerebrovascular events (MACCE) at 12 months and 30 days as well as with perioperative myocardial injury (PMI).

methodsWe conducted a prospective observational cohort study of adults undergoing noncardiac surgery with intermediate to high surgical risk in Basel, Switzerland, and Düsseldorf, Germany from February 2016 to December 2020. We measured copeptin and cardiac troponin before surgery, immediately after surgery (0 hr) and once between the second and fourth postoperative day (POD 2-4).

resultsA primary outcome event of a composite of all-cause mortality and/or MACCE at 12 months occurred in 48/502 patients (9.6%). Elevated preoperative copeptin (> 14 pmol·L

conclusionThe results of the present prospective observational cohort study suggest that perioperative copeptin concentrations can help identify patients at risk for all-cause mortality and/or MACCE. Other identified risk factors were revised cardiac risk index, body mass index, surgical risk, and preoperative hemoglobin.

trial registrationClinicalTrials.gov (NCT02687776); first submitted 9 February 2016.

Indexed as

GlycopeptidesPostoperative ComplicationsAdultHumansProspective StudiesRisk AssessmentRisk FactorscopeptinsGlycopeptidesmajor cardiovascular and cerebrovascular events (MACCE)perioperative copeptinperioperative myocardial injuryperioperative risk stratification

Identifiers

PMID38243094
PMCPMC10923994
OpenAlexW4391014359

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.