Evidence map›Paper›PMID 38242960›Full record

ArticleScientific reports2024

Gastroprotective effect of rhodanine and 2,4-thiazolidinediones scaffolds in rat stomachs by contribution of anti-apoptotic (BCL-2) and tumor suppressor (P53) proteins.

Rozh Q Ameen, Zahra A Amin, Hiwa O Ahmad, Diler D Ghafur, Melodya G Toma, Nyan Sabah, Muhammad Fakhir, Gardoon Abdulla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rozh Q AmeenDepartment of Pharmacy, Paitaxt Technical Institute, Erbil, Kurdistan Region, Iraq.
Zahra A AminDepartment of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, 44001, Iraq.
Hiwa O AhmadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, 44001, Iraq. hiwa.omar@hmu.edu.krd.
Diler D GhafurDepartment of Chemistry, College of Education, Salahaddin University, Erbil, Kurdistan Region, Iraq.
Melodya G TomaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, 44001, Iraq.
Nyan SabahDepartment of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, 44001, Iraq.
Muhammad FakhirDepartment of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, 44001, Iraq.
Gardoon AbdullaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, 44001, Iraq.
Hawler Medical University · IQSalahaddin University-Erbil · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent times, the methods used to evaluate gastric ulcer healing worldwide have been based on visual examinations and estimating ulcer dimensions in experimental animals. In this study, the protective effect of rhodanine and 2,4-thiazolidinediones scaffolds compared to esomeprazole was investigated in an ethanol model of stomach ulcers in rats. Pretreatment with experimental treatments or esomeprazole prevented the development of ethanol-induced gastric ulcers. The severity of the lesions and injuries was significantly lower than that of vehicle (10% Tween 80) treated rats. Significant and excellent results were obtained with the compound 6 group, with inhibition percentage and ulcer area values of 97.8% and 12.8 ± 1.1 mm

Indexed as

Anti-Ulcer AgentsRhodanineStomach UlcerThiazolidinedionesAdenosine TriphosphatasesAnimalsEsomeprazoleEthanolGastric MucosaHumansPlant ExtractsPolysorbatesProto-Oncogene Proteins c-bcl-2RatsTumor Suppressor Protein p53Ulcer2,4-thiazolidinedioneAdenosine TriphosphatasesAnti-Ulcer AgentsEsomeprazoleEthanolPlant ExtractsPolysorbatesProto-Oncogene Proteins c-bcl-2RhodanineThiazolidinedionesTumor Suppressor Protein p53

Identifiers

PMID38242960
PMCPMC10799065
OpenAlexW4391028614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.