Evidence map›Paper›PMID 38242926›Full record

ArticleScientific data2024

Annotated dataset for training deep learning models to detect astrocytes in human brain tissue.

Alex Olar, Teadora Tyler, Paulina Hoppa, Erzsébet Frank, István Csabai, Istvan Adorjan, Péter Pollner

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alex OlarEötvös Loránd University, Department of Physics of Complex Systems, Budapest, Hungary.ORCID 0000-0001-8094-4324
Teadora TylerSemmelweis University, Department of Anatomy, Histology and Embryology, Budapest, Hungary.
Paulina HoppaSemmelweis University, Department of Anatomy, Histology and Embryology, Budapest, Hungary.
Erzsébet FrankSemmelweis University, Department of Anatomy, Histology and Embryology, Budapest, Hungary.
István CsabaiEötvös Loránd University, Department of Physics of Complex Systems, Budapest, Hungary.
Istvan AdorjanSemmelweis University, Department of Anatomy, Histology and Embryology, Budapest, Hungary. adorjan.istvan@semmelweis.hu.
Péter PollnerSemmelweis University, Data-Driven Health Division of National Laboratory for Health Security, Health Services Management Training Centre, Budapest, Hungary. peter.pollner@emk.semmelweis.hu.
Semmelweis University · HUEötvös Loránd University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocytes, a type of glial cell, significantly influence neuronal function, with variations in morphology and density linked to neurological disorders. Traditional methods for their accurate detection and density measurement are laborious and unsuited for large-scale operations. We introduce a dataset from human brain tissues stained with aldehyde dehydrogenase 1 family member L1 (ALDH1L1) and glial fibrillary acidic protein (GFAP). The digital whole slide images of these tissues were partitioned into 8730 patches of 500 × 500 pixels, comprising 2323 ALDH1L1 and 4714 GFAP patches at a pixel size of 0.5019/pixel, furthermore 1382 ADHD1L1 and 311 GFAP patches at 0.3557/pixel. Sourced from 16 slides and 8 patients our dataset promotes the development of tools for glial cell detection and quantification, offering insights into their density distribution in various brain areas, thereby broadening neuropathological study horizons. These samples hold value for automating detection methods, including deep learning. Derived from human samples, our dataset provides a platform for exploring astrocyte functionality, potentially guiding new diagnostic and treatment strategies for neurological disorders.

Indexed as

Deep LearningNervous System DiseasesAstrocytesBrainHumansNeuroglia

Identifiers

PMID38242926
PMCPMC10798998
OpenAlexW4391026970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.