ArticleNature human behaviour2024
A generative model of memory construction and consolidation.
Article in Nature human behaviour, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Efficacy and Safety of Mobile App-Based Metamemory Cognitive Training for Mild Cognitive Impairment: Multicenter Randomized Clinical Trial.JMIR mHealth and uHealth · 2026Trial
- Retrieval practice promotes semantic integration of real-world memories without compromising episodic integrity.Psychonomic bulletin & review · 2026Article
- Hippocampal ripples initiate cortical dimensionality expansion for memory retrieval.Nature communications · 2026Article
- The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Hippocampo-neocortical interaction as compressive retrieval-augmented generation.Nature communications · 2026Article
- Moderating role of executive function in the relationship between specific white matter changes and long-term delayed recall in aMCI patients.Alzheimer's research & therapy · 2026Article
- Article
- Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex.Communications biology · 2026Article
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- Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer's disease.Molecular neurodegeneration advances · 2026Article
- The active construction of past episodes.Translational neuroscience · 2026Article
- Composing egocentric and allocentric maps for flexible navigation.PLoS computational biology · 2026Article
- Cross-modular integration and the missing mechanism in biocultural accounts of language.Frontiers in psychology · 2026Article
- Dynamic Synchronization and Resonance as the Origin of 1/f Fluctuations-Amplitude Modulation Across Music and Nature.Entropy (Basel, Switzerland) · 2025Article
- Hippocampal-prefrontal orchestration supports higher-order learning for creative ideation.Nature communications · 2025Article
- Cognitive Maps in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- A compressed code for memory discrimination.bioRxiv : the preprint server for biology · 2025Article
- An embedded computational framework of memory: The critical role of representations in veridical and false recall predictions.Psychonomic bulletin & review · 2025Review
- Task-relevant representational spaces in human memory traces.PLoS computational biology · 2025Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Episodic memories are (re)constructed, share neural substrates with imagination, combine unique features with schema-based predictions and show schema-based distortions that increase with consolidation. Here we present a computational model in which hippocampal replay (from an autoassociative network) trains generative models (variational autoencoders) to (re)create sensory experiences from latent variable representations in entorhinal, medial prefrontal and anterolateral temporal cortices via the hippocampal formation. Simulations show effects of memory age and hippocampal lesions in agreement with previous models, but also provide mechanisms for semantic memory, imagination, episodic future thinking, relational inference and schema-based distortions including boundary extension. The model explains how unique sensory and predictable conceptual elements of memories are stored and reconstructed by efficiently combining both hippocampal and neocortical systems, optimizing the use of limited hippocampal storage for new and unusual information. Overall, we believe hippocampal replay training generative models provides a comprehensive account of memory construction, imagination and consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.