Evidence map›Paper›PMID 38242802›Full record

Trial reportBritish journal of anaesthesia2024

Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial.

Sina Krone, Michael P Bokoch, Rishi Kothari, Nicholas Fong, Roberta T Tallarico, Jillene Sturgess-DaPrato, Romain Pirracchio, Alexander Zarbock, Matthieu Legrand

2 registry-linked trialsOpen access · hybridAbstract readRandomized Controlled TrialMulticenter StudyPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04789330 phase4completednot on this map

The Choice of Vasopressor for Treating Hypotension During General Anesthesia: a Pilot Pragmatic Cluster Cross-over Randomized Trial (the VEGA-1 Trial)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2021 to 2022Enrolled3,626ConditionsAnesthesia, Surgery, HypotensionArmsNorepinephrine, Phenylephrine
NCT07164339 active not recruitingnot on this map

Association Between Intraoperative Perfusion Index and Mortality

TypeobservationalSponsorCopenhagen University Hospital, HvidovreRan2024 to 2025Enrolled425,000ConditionsHemodynamic, Perfusion Index, Intraoperative Hemodyamic Monitoring
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sina KroneDepartment of Anesthesiology and Perioperative Care, University of California, San Francisco, CA, USA; Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Michael P BokochDepartment of Anesthesiology and Perioperative Care, University of California, San Francisco, CA, USA.
Rishi KothariDepartment of Anesthesiology and Perioperative Care, University of California, San Francisco, CA, USA.
Nicholas FongDepartment of Anesthesiology and Perioperative Care, University of California, San Francisco, CA, USA.
Roberta T TallaricoDepartment of Anesthesiology and Perioperative Care, University of California, San Francisco, CA, USA.
Jillene Sturgess-DaPratoDepartment of Anesthesiology and Perioperative Care, University of California, San Francisco, CA, USA.
Romain PirracchioDepartment of Anesthesiology and Perioperative Care, University of California, San Francisco, CA, USA.
Alexander ZarbockDepartment of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.
Matthieu LegrandDepartment of Anesthesiology and Perioperative Care, University of California, San Francisco, CA, USA; INI-CRCT Network, Nancy, France. Electronic address: Matthieu.Legrand@ucsf.edu.
University of California, San Francisco · USUniversity Hospital Münster · DE

Funding

Comprehensive Anesthesia Research TrainingT32GM008440 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Judith Hellman · 1996 to 2026
$5.5M
The choice of vasopressor to prevent postoperative acute kidney injury after major non-cardiac surgery: a multicenter pragmatic cluster cross-over randomized trial (the VEGA-2 trial)R01DK139484 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SACHIN KHETERPAL, Matthieu Legrand · 2024 to 2026
$2.0M
Identification of sub-phenotypes of severely ill burn patients and risk for secondary sepsis: SEPSISBURNR01GM151494 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthieu Legrand · 2023 to 2026
$1.5M
NIDDK NIH HHS R01 DK139484NIGMS NIH HHS R01 GM151494NIGMS NIH HHS T32 GM008440
6 · The paper itself

Abstract

backgroundThe peripheral perfusion index is the ratio of pulsatile to nonpulsatile static blood flow obtained by photoplethysmography and reflects peripheral tissue perfusion. We investigated the association between intraoperative perfusion index and postoperative acute kidney injury in patients undergoing major noncardiac surgery and receiving continuous vasopressor infusions.

methodsIn this exploratory post hoc analysis of a pragmatic, cluster-randomised, multicentre trial, we obtained areas and cumulative times under various thresholds of perfusion index and investigated their association with acute kidney injury in multivariable logistic regression analyses. In secondary analyses, we investigated the association of time-weighted average perfusion index with acute kidney injury. The 30-day mortality was a secondary outcome.

resultsOf 2534 cases included, 8.9% developed postoperative acute kidney injury. Areas and cumulative times under a perfusion index of 3% and 2% were associated with an increased risk of acute kidney injury; the strongest association was observed for area under a perfusion index of 1% (adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.00-1.74, P=0.050, per 100%∗min increase). Additionally, time-weighted average perfusion index was associated with acute kidney injury (aOR 0.82, 95% CI 0.74-0.91, P<0.001) and 30-day mortality (aOR 0.68, 95% CI 0.49-0.95, P=0.024).

conclusionsLarger areas and longer cumulative times under thresholds of perfusion index and lower time-weighted average perfusion index were associated with postoperative acute kidney injury in patients undergoing major noncardiac surgery and receiving continuous vasopressor infusions. CLINICAL

trial registrationNCT04789330.

Indexed as

Acute Kidney InjuryHypotensionHumansPerfusion IndexPostoperative ComplicationsRetrospective StudiesRisk Factorsacute kidney injuryhaemodynamicsintraoperative hypotensionperioperative outcomesperipheral perfusion index

Identifiers

PMID38242802
PMCPMC13639447
OpenAlexW4391056215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.