Evidence map›Paper›PMID 38242778›Full record

ArticleJournal of cardiovascular computed tomography

Motion correction of wide-detector 4DCT images for cardiac resynchronization therapy planning.

Ashish Manohar, James Yang, Jed D Pack, Gordon Ho, Elliot R McVeigh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashish ManoharDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA; Department of Radiology, Stanford University, Stanford, CA, USA; Cardiovascular Institute, Stanford University, Stanford, CA, USA.
James YangDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Jed D PackRadiation Systems Lab, GE Global Research, Niskayuna, New York, USA.
Gordon HoDepartment of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Elliot R McVeighDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA; Department of Medicine, Division of Cardiology, University of California San Diego, La Jolla, CA, USA; Department of Radiology, University of California San Diego, La Jolla, CA, USA. Electronic address: emcveigh@ucsd.edu.

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
True 4DCT for Quantifying LV Dyssynchrony and Function for Targeting LV Lead Location in CRTR01HL144678 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCVEIGH, ELLIOT R · 2019 to 2022
$3.3M
Patient-specific thrombosis risk in atrial fibrillation by 4D CT imaging of atrial kinetics combined with computational fluid dynamicsR01HL160024 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEL ALAMO, JUAN CARLOS, KAHN, ANDREW · 2021 to 2024
$2.7M
NCATS NIH HHS KL2 TR001444NHLBI NIH HHS R01 HL144678NHLBI NIH HHS R01 HL160024
6 · The paper itself

Abstract

backgroundLead placement at the latest mechanically activated left ventricle (LV) segments is strongly correlated with response to cardiac resynchronization therapy (CRT). We demonstrate the feasibility of a cardiac 4DCT motion correction algorithm (ResyncCT) in estimating LV mechanical activation for guiding lead placement in CRT.

methodsSubjects with full cardiac cycle 4DCT images acquired using a wide-detector CT scanner for CRT planning/upgrade were included. 4DCT images exhibited motion artifact-induced false-dyssynchrony, hindering LV mechanical activation time estimation. Motion-corrupted images were processed with ResyncCT to yield motion-corrected images. Time to onset of shortening (TOS) was estimated in each of 72 endocardial segments. A false-dyssynchrony index (FDI) was used to quantify the extent of motion artifacts in the uncorrected and the ResyncCT images. After motion correction, the change in classification of LV free-wall segments as optimal target sites for lead placement was investigated.

resultsTwenty subjects (70.7 ​± ​13.9 years, 6 female) were analyzed. Motion artifacts in the ResyncCT-processed images were significantly reduced (FDI: 28.9 ​± ​9.3 ​% vs 47.0 ​± ​6.0 ​%, p ​< ​0.001). In 10 (50 ​%) subjects, ResyncCT motion correction yielded statistically different TOS estimates (p ​< ​0.05). Additionally, 43 ​% of LV free-wall segments were reclassified as optimal target sites for lead placement after motion correction.

conclusionsResyncCT significantly reduced motion artifacts in wide-detector cardiac 4DCT images, yielded statistically different time to onset of shortening estimates, and changed the location of optimal target sites for lead placement. These results highlight the potential utility of ResyncCT motion correction in CRT planning when using wide-detector 4DCT imaging.

Indexed as

Cardiac Resynchronization TherapyHeart FailureFemaleHeartHeart VentriclesHumansPredictive Value of TestsTreatment OutcomeCardiac 4DCTCardiac resynchronization therapyLV mechanical activationMotion correction

Identifiers

PMID38242778
PMCPMC11087942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.