Evidence map›Paper›PMID 38242697›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Alleviating Hypertension by Selectively Targeting Angiotensin Receptor-Expressing Vagal Sensory Neurons.

Caitlin Baumer-Harrison, Khalid Elsaafien, Dominique N Johnson, Jesus D Peñaloza Aponte, Alan de Araujo, Sagar Patel, Erin B Bruce, Scott W Harden, Charles J Frazier, Karen A Scott and 3 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Cardiac vagal motor neurons.Current opinion in neurobiology · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Homeostatic Signal Convergence in Vagal Baroreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Caitlin Baumer-HarrisonDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida 32611.ORCID 0000-0002-6287-5887
Khalid ElsaafienCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, Florida 32611.
Dominique N JohnsonCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, Florida 32611.
Jesus D Peñaloza AponteDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida 32611.ORCID 0000-0001-5903-2291
Alan de AraujoMonell Chemical Senses Center, Philadelphia, Pennsylvania 19104.
Sagar PatelDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida 32611.
Erin B BruceDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida 32611.
Scott W HardenCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, Florida 32611.
Charles J FrazierCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, Florida 32611.ORCID 0000-0003-3550-4789
Karen A ScottCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, Florida 32611.
Guillaume de LartigueMonell Chemical Senses Center, Philadelphia, Pennsylvania 19104.
Eric G KrauseCenter for Integrative Cardiovascular and Metabolic Diseases, University of Florida, Gainesville, Florida 32611.
Annette D de KloetDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, Florida 32611 adekloet@gsu.edu.
University of Florida · USGeorgia State University · USMonell Chemical Senses Center · USFlorida College of Integrative Medicine · US

Funding

Interrogating stress-relieving neural circuits to alleviate cardiovascular diseaseR35HL150750 · NHLBI · UNIVERSITY OF FLORIDA · PI Eric Gerald Krause · 2020 to 2026
$5.9M
Neurons expressing angiotensin type 2 receptors in the NTS as an access point for cardiovascular control.R01HL136595 · NHLBI · UNIVERSITY OF FLORIDA · PI COLIN SUMNERS, Annette Diane de Kloet · 2018 to 2026
$4.8M
Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertensionR01HL145028 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2019 to 2023
$1.9M
Training Program in Chemosensory ScienceT32DC015994 · NIDCD · UNIVERSITY OF FLORIDA · PI Daniel W Wesson · 2018 to 2026
$1.4M
Novel role of central AT2R in blood pressure regulationK99HL125805 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2015 to 2016
$225k
Gustatory and interoceptive regulation of hypertensionF31HL162540 · NHLBI · UNIVERSITY OF FLORIDA · PI BAUMER HARRISON, CAITLIN MARIE · 2022 to 2023
$67k
NHLBI NIH HHS F31 HL162540NHLBI NIH HHS K99 HL125805NHLBI NIH HHS R01 HL136595NHLBI NIH HHS R01 HL145028NHLBI NIH HHS R35 HL150750NIDCD NIH HHS T32 DC015994
6 · The paper itself

Abstract

Cardiovascular homeostasis is maintained, in part, by neural signals arising from arterial baroreceptors that apprise the brain of blood volume and pressure. Here, we test whether neurons within the nodose ganglia that express angiotensin type-1a receptors (referred to as NG

Indexed as

Desoxycorticosterone AcetateHypertensionRed Fluorescent ProteinAnimalsBlood PressureFemaleIon ChannelsMaleMicePhenylephrineSensory Receptor CellsSolitary NucleusDesoxycorticosterone AcetateIon ChannelsPhenylephrinePiezo1 protein, mouseRed Fluorescent ProteintdTomatoautonomicbaroreceptorbaroreflexblood pressurenodosevagus

Identifiers

PMID38242697
PMCPMC10904025
OpenAlexW4391019969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.