ArticleCell reports. Medicine2024
Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors.
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Article in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
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Who cites it
34 citing papers in PubMed, 27 citations in OpenAlex.
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- Myeloid-derived suppressor cells in cancer: biology, regulatory networks and theranostic prospects.Signal transduction and targeted therapy · 2026Review
- Targeting a Myeloid-Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Human immunosuppressive neutrophils: recent answers to old and new questions.The EMBO journal · 2026Review
- CFTR modulators exert subset-specific phenotype remodeling on circulating neutrophils in cystic fibrosis.ImmunoHorizons · 2026Article
- Immune Escape in Renal Cell Carcinoma: Latest Research and Treatment Strategies.International journal of molecular sciences · 2026Review
- Article
- Systematic Evaluation of Physicochemical Properties of PEGylated Gold Nanorods Reveals Cell-Specific Uptake Determinants in Human Immune Cell Subsets.Small science · 2026Article
- Hepatocytes functionally reprogrammed by KIAA1199-high colorectal cancer cells favour the accumulation of pro-metastatic Egr1Nature communications · 2026Article
- Prostate Cancer: Dissecting Novel Immunosuppressive Mechanisms Through Context-Specific Transcriptomic Programs and MDSC Cells.International journal of molecular sciences · 2026Article
- Myeloid-derived suppressor cells in laryngeal squamous cell carcinoma: an underexplored immunosuppressive axis and strategic target for overcoming checkpoint inhibitor resistance.Frontiers in immunology · 2026Review
- Myeloid-Derived Suppressor Cells: Immunoregulatory Roles and Therapeutic Prospects in Immune-Mediated Hematological Disorders.Journal of immunology research · 2026Review
- Influenza virus infection drives upregulation of CD84 across a broad range of immune cells.Clinical & translational immunology · 2026Article
- Neutrophils suppress adaptive αβ T cells but not the innate γδ T cells and natural killer cells.Frontiers in immunology · 2026Article
- Tumor-associated neutrophils in lung adenocarcinoma: from mechanisms to therapeutic targeting.Frontiers in immunology · 2026Review
- Review
- The composition of MDSC-subpopulations PMN-like, M-like, and e-like MDSC is associated with the severity of infectious mononucleosis in pediatric patients.Frontiers in immunology · 2026Article
- Targeting innate immunity in cancer: mechanistic foundations, therapeutic vaccination, and clinical translation.Frontiers in immunology · 2026Review
- Identification of immunosuppressive neutrophils using multi-omics: why functional testing remains key.Frontiers in immunology · 2026Review
- Hypoxia-induced EGR1 remodels neutrophils to suppress antitumor immunity.Science immunology · 2025Article
Corrections and comments
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Authors and funding
35 authors at 4 institutions in 3 countries.
Francesca PettinellaSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Barbara MariottiSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Chiara LattanziSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Kirsten BruderekResearch Division, Department of Otorhinolaryngology, University Hospital Essen, 45122 Essen, Germany.
Marta DoniniSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Sara CostaSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Olivia MariniSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Giulia IannotoSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Sara GasperiniSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Elena CaveggionSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Monica CastellucciCentro Piattaforme Tecnologiche, University of Verona, Verona, Italy.
Federica CalzettiSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Francisco Bianchetto-AguileraSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Elisa GardimanSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Matteo GianiSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Stefano DusiSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Maurizio CantiniTransfusion Medicine Department, University and Hospital Trust (AOUI), Verona, Italy.
Aurora VassanelliTransfusion Medicine Department, University and Hospital Trust (AOUI), Verona, Italy.
Denise PavoneTransfusion Medicine Department, University and Hospital Trust (AOUI), Verona, Italy.
Michele MilellaSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Verona, Italy.
Sara PilottoSection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Verona, Italy.
Pamela BiondaniSection of Oncology, University and Hospital Trust (AOUI) of Verona, Verona, Italy.
Benedikt HöingDepartment of Otorhinolaryngology, University Hospital Essen, Essen, Germany.
Marie Carolin SchleupnerDepartment of Otorhinolaryngology, University Hospital Essen, Essen, Germany.
Timon HussainDepartment of Otorhinolaryngology, University Hospital Essen, Essen, Germany.
Boris HadaschikDepartment of Urology, University Hospital Essen, Essen, Germany.
Cordelia KasparDepartment of Urology, University Hospital Essen, Essen, Germany.
Carlo ViscoSection of Hematology and Bone Marrow Transplant Unit, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Verona, Italy.
Cristina TecchioSection of Hematology and Bone Marrow Transplant Unit, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Verona, Italy.
Leo KoendermanDepartment of Respiratory Medicine and Center for Translational Immunology, University Medical Center Utrecht, 3584CX Utrecht, the Netherlands.
Flavia BazzoniSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Nicola TamassiaSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy.
Sven BrandauResearch Division, Department of Otorhinolaryngology, University Hospital Essen, 45122 Essen, Germany; German Cancer Consortium, Partner Site Essen-Düsseldorf, Essen, Germany.
Marco A CassatellaSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy. Electronic address: marco.cassatella@univr.it.
Patrizia ScapiniSection of General Pathology, Department of Medicine, University of Verona, 37134 Verona, Italy. Electronic address: patrizia.scapini@univr.it.
University of Verona · ITEssen University Hospital · DEDüsseldorf University Hospital · DEUniversity Medical Center Utrecht · NL
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precise molecular characterization of circulating polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is hampered by their mixed composition of mature and immature cells and lack of specific markers. Here, we focus on mature CD66b
Indexed as
Myeloid-Derived Suppressor CellsNeoplasmsCD52 AntigenGranulocyte Colony-Stimulating FactorHumansNeutrophilsReceptors, Prostaglandin E, EP2 SubtypeSignaling Lymphocytic Activation Molecule FamilyCD52 AntigenCD52 protein, humanCD84 protein, humanGranulocyte Colony-Stimulating FactorPTGER2 protein, humanReceptors, Prostaglandin E, EP2 SubtypeSignaling Lymphocytic Activation Molecule Familybiomarkerscancer patientsG-CSFneutrophilsPMN-MDSCs
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