Evidence map›Paper›PMID 38242087›Full record

ArticleCell2024

Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective.

Radhika Mathur, Qixuan Wang, Patrick G Schupp, Ana Nikolic, Stephanie Hilz, Chibo Hong, Nadia R Grishanina, Darwin Kwok, Nicholas O Stevers, Qiushi Jin and 20 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 3 pooled it
39.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 3 syntheses or guidelines pooled it, 168 citations in OpenAlex.

  1. Pooled it
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  11. Translational Theranostics in Glioblastoma: FAPI-46 as a Precision Medicine Tool.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
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  16. Mechanisms, Microenvironments, and Models: Understanding Therapeutic Resistance in Glioblastoma.International journal of radiation oncology, biology, physics · 2026
    Review
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101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 4 institutions in 2 countries.

Radhika MathurDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Qixuan WangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Patrick G SchuppDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Ana NikolicDepartment of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB.
Stephanie HilzDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Chibo HongDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Nadia R GrishaninaDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Darwin KwokDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Nicholas O SteversDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Qiushi JinDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Mark W YoungbloodDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lena Ann StasiakDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ye HouDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Juan WangDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Takafumi N YamaguchiDepartment of Human Genetics, University of California, Los Angeles, Los Angees, CA, USA.
Marisa LafontaineDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Anny ShaiDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Ivan V SmirnovDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
David A SolomonDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Susan M ChangDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Shawn L Hervey-JumperDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Mitchel S BergerDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Janine M LupoDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Hideho OkadaDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Joanna J PhillipsDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Paul C BoutrosDepartment of Human Genetics, University of California, Los Angeles, Los Angees, CA, USA.
Marco GalloDepartment of Biochemistry & Molecular Biology, University of Calgary, Calgary, AB; Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Michael C OldhamDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Feng YueDepartment of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: yue@northwestern.edu.
Joseph F CostelloDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: joseph.costello@ucsf.edu.
University of California, San Francisco · USNorthwestern University · USUniversity of Calgary · CAUniversity of California, Los Angeles · US

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pavithra Viswanath · 2007 to 2026
$44.7M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
Preclinical development of breakthrough immunotherapy for brain tumorsR35NS105068 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OKADA, HIDEHO · 2018 to 2025
$6.0M
Impact of genetic variants on gene regulation and 3D genome organization in human diseasesR35GM124820 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Feng Yue · 2017 to 2026
$4.0M
Imaging Guided Genomics of Malignant TransformationR01CA169316 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COSTELLO, JOSEPH F · 2013 to 2017
$3.0M
Multiscale transcriptional architecture of the human brainR01MH123156 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OLDHAM, MICHAEL CLARK · 2020 to 2023
$2.4M
Decoding the molecular basis of cellular identity in adult malignant gliomasR01CA244621 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OLDHAM, MICHAEL CLARK · 2020 to 2024
$2.1M
Decoding the molecular basis of cellular identity in the human brainR01MH113896 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OLDHAM, MICHAEL CLARK · 2018 to 2022
$2.0M
Visualization, modeling and validation of chromatin interaction dataR01HG009906 · NHGRI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI YUE, FENG · 2018 to 2022
$2.0M
Mitigation of preanalytic factors influencing brain tumor protein phosphorylationU01CA229345 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PHILLIPS, JOANNA · 2019 to 2023
$1.8M
Computational methods to identify neo-TADs and enhancer-hijacking in rearranged genomesR01HG011207 · NHGRI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YUE, FENG · 2021 to 2024
$1.6M
NCI NIH HHS F32 CA239472NCI NIH HHS P01 CA118816NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA169316NCI NIH HHS R01 CA244621NCI NIH HHS R50 CA274229NCI NIH HHS T32 CA151022NCI NIH HHS U01 CA229345NHGRI NIH HHS R01 HG009906NHGRI NIH HHS R01 HG011207NIGMS NIH HHS R35 GM124820NIMH NIH HHS R01 MH113896NIMH NIH HHS R01 MH123156NINDS NIH HHS R35 NS105068
6 · The paper itself

Abstract

Treatment failure for the lethal brain tumor glioblastoma (GBM) is attributed to intratumoral heterogeneity and tumor evolution. We utilized 3D neuronavigation during surgical resection to acquire samples representing the whole tumor mapped by 3D spatial coordinates. Integrative tissue and single-cell analysis revealed sources of genomic, epigenomic, and microenvironmental intratumoral heterogeneity and their spatial patterning. By distinguishing tumor-wide molecular features from those with regional specificity, we inferred GBM evolutionary trajectories from neurodevelopmental lineage origins and initiating events such as chromothripsis to emergence of genetic subclones and spatially restricted activation of differential tumor and microenvironmental programs in the core, periphery, and contrast-enhancing regions. Our work depicts GBM evolution and heterogeneity from a 3D whole-tumor perspective, highlights potential therapeutic targets that might circumvent heterogeneity-related failures, and establishes an interactive platform enabling 360° visualization and analysis of 3D spatial patterns for user-selected genes, programs, and other features across whole GBM tumors.

Indexed as

Brain NeoplasmsGlioblastomaModels, BiologicalEpigenomicsGenetic HeterogeneityGenomicsHumansSingle-Cell AnalysisTumor Microenvironmentbrain tumorschromatin accessibilitychromatin interactionsepigenomicsgenomicsglioblastomaintratumoral heterogeneitymicroenvironmentspatial analysistumor evolution

Identifiers

PMID38242087
PMCPMC10832360
OpenAlexW4391004205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.