Evidence map›Paper›PMID 38241945›Full record

ArticleUltrasonics sonochemistry2024

Enhanced macromolecular substance extravasation through the blood-brain barrier via acoustic bubble-cell interactions.

Jifan Chen, Jean-Michel Escoffre, Oliver Romito, Tarik Iazourene, Antoine Presset, Marie Roy, Marie Potier Cartereau, Christophe Vandier, Yahua Wang, Guowei Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics sonochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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  6. Reversible CaUltrasonics sonochemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Jifan ChenDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Zhejiang, China; Inserm UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Jean-Michel EscoffreInserm UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Oliver RomitoInserm UMR 1069 Nutrition, Croissance et Cancer (N2C), Faculté de Médecine, Université de Tours, F-37032, France.
Tarik IazoureneInserm UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Antoine PressetInserm UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Marie RoyInserm UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Marie Potier CartereauInserm UMR 1069 Nutrition, Croissance et Cancer (N2C), Faculté de Médecine, Université de Tours, F-37032, France.
Christophe VandierInserm UMR 1069 Nutrition, Croissance et Cancer (N2C), Faculté de Médecine, Université de Tours, F-37032, France.
Yahua WangInserm UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.
Guowei WangDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Zhejiang, China.
Pintong HuangDepartment of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Zhejiang, China; Research Center for Life Science and Human Health, Binjiang Institute of Zhejiang University, Hangzhou 310053, China. Electronic address: huangpintong@zju.edu.cn.
Ayache BouakazInserm UMR 1253, iBrain, Université de Tours, Inserm, Tours, France. Electronic address: ayache.bouakaz@univ-tours.fr.
Université de Tours · FRSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) maintains brain homeostasis, regulates influx and efflux transport, and provides protection to the brain tissue. Ultrasound (US) and microbubble (MB)-mediated blood-brain barrier opening is an effective and safe technique for drug delivery in-vitro and in-vivo. However, the exact mechanism underlying this technique is still not fully elucidated. The aim of the study is to explore the contribution of transcytosis in the BBB transient opening using an in-vitro model of BBB. Utilizing a diverse set of techniques, including Ca

Indexed as

Blood-Brain BarrierDextransAcousticsBrainCell CommunicationColoring AgentsDrug Delivery SystemsMicrobubblesColoring AgentsDextransBlood-brain barrierBubble-cell mechanical interactionDrug deliveryIn-vitroMacromolecular substanceMicrobubblesTranscytosisUltrasound

Identifiers

PMID38241945
PMCPMC10825521
OpenAlexW4391056147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.