Evidence map›Paper›PMID 38241465›Full record

ArticleJournal of the American Geriatrics Society2024

Diagnostic uncertainty and decision-making in home-based primary care: A qualitative study of antibiotic prescribing.

Rupak Datta, Eliza Kiwak, Terri R Fried, Andrea Benjamin, Lynne Iannone, Sarah L Krein, Warren Carter, Andrew B Cohen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Rupak DattaVeterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.ORCID 0000-0003-2281-7508
Eliza KiwakDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Terri R FriedVeterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.ORCID 0000-0001-8083-8265
Andrea BenjaminDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Lynne IannoneVeterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.
Sarah L KreinVeterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.
Warren CarterDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Andrew B CohenVeterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.ORCID 0000-0001-9161-8436
Yale University · USUniversity of Michigan · US

Funding

Training Core (I)U54AG063546 · NIA · BROWN UNIVERSITY · PI Abraham Aizer Brody, SUSAN L MITCHELL · 2019 to 2026
$125.9M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
Dementia and Decision-Making for Older Adults without SurrogatesK76AG059987 · NIA · YALE UNIVERSITY · PI COHEN, ANDREW B · 2018 to 2022
$1.2M
NIA Short Term Research Training: Students in Health Professional SchoolsT35AG049685 · NIA · YALE UNIVERSITY · PI Sarwat I Chaudhry, Terri R. Fried · 2016 to 2026
$804k
Research Career Scientist AwardIK6HX003399 · VA · VETERANS HEALTH ADMINISTRATION · PI KREIN, SARAH · 2023 to 2025
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HSRD VA IK6 HX003399NCATS NIH HHS UL1 TR001863NIA NIH HHS K76 AG059987NIA NIH HHS K76AG059987NIA NIH HHS P30 AG021342NIA NIH HHS T35 AG049685NIA NIH HHS U54 AG063546NIA NIH HHS U54AG063546
6 · The paper itself

Abstract

backgroundEvaluating infection in home-based primary care is challenging, and these challenges may impact antibiotic prescribing. A refined understanding of antibiotic decision-making in this setting can inform strategies to promote antibiotic stewardship. This study investigated antibiotic decision-making by exploring the perspectives of clinicians in home-based primary care.

methodsClinicians from the Department of Veterans Affairs Home-Based Primary Care Program were recruited. Semi-structured interviews were conducted from June 2022 through September 2022 using a discussion guide. Transcripts were analyzed using grounded theory. The constant comparative method was used to develop a coding structure and to identify themes.

resultsTheoretical saturation was reached after 22 clinicians (physicians, n = 7; physician assistants, n = 2, advanced practice registered nurses, n = 13) from 19 programs were interviewed. Mean age was 48.5 ± 9.3 years, 91% were female, and 59% had ≥6 years of experience in home-based primary care. Participants reported uncertainty about the diagnosis of infection due to the characteristics of homebound patients (atypical presentations of disease, presence of multiple chronic conditions, presence of cognitive impairment) and the challenges of delivering medical care in the home (limited access to diagnostic testing, suboptimal quality of microbiological specimens, barriers to establishing remote access to the electronic health record). When faced with diagnostic uncertainty about infection, participants described many factors that influenced the decision to prescribe antibiotics, including those that promoted prescribing (desire to avoid hospitalization, pressure from caregivers, unreliable plans for follow-up) and those that inhibited prescribing (perceptions of antibiotic-associated harms, willingness to trial non-pharmacological interventions first, presence of caregivers who were trusted by clinicians to monitor symptoms).

conclusionsClinicians face the difficult task of balancing diagnostic uncertainty with many competing considerations during the treatment of infection in home-based primary care. Recognizing these issues provides insight into strategies to promote antibiotic stewardship in home care settings.

Indexed as

Anti-Bacterial AgentsHome Care ServicesPrimary Health CareQualitative ResearchAdultAntimicrobial StewardshipClinical Decision-MakingDecision MakingFemaleHumansMaleMiddle AgedPractice Patterns, Physicians'UncertaintyUnited StatesUnited States Department of Veterans AffairsAnti-Bacterial Agentsanti‐bacterial agentsdiagnosishome care servicesinfectionsuncertainty

Identifiers

PMID38241465
PMCPMC11090732
OpenAlexW4391018090

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.