Evidence map›Paper›PMID 38241368›Full record

ArticleScience advances2024

Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages.

Minh Binh Nguyen, Pooja Flora, Meagan C Branch, Madison Weber, Xiang Yu Zheng, Unnikrishnan Sivan, Simon Joost, Karl Annusver, Deyou Zheng, Maria Kasper and 1 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Development and regeneration of Merkel cells.Current topics in developmental biology · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Minh Binh NguyenBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0004-8020-9767
Pooja FloraBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0443-4511
Meagan C BranchBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4630-5825
Madison WeberBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xiang Yu ZhengDepartment of Genetics, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-8656-6598
Unnikrishnan SivanDepartment of Neurology, and Neuroscience, Albert Einstein College of Medicine, New York, NY, USA.
Simon JoostDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.ORCID 0000-0001-6661-541X
Karl AnnusverDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.ORCID 0000-0002-9515-7216
Deyou ZhengDepartment of Genetics, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0003-4354-5337
Maria KasperDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Elena EzhkovaBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-4154-1615
Icahn School of Medicine at Mount Sinai · USAlbert Einstein College of Medicine · USKarolinska Institutet · SE

Funding

Skin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2M
Toward understanding the molecular mechanisms of Merkel cell fate determinationR01AR063724 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EZHKOVA, ELENA · 2012 to 2021
$4.2M
NIAMS NIH HHS P30 AR079200NIAMS NIH HHS R01 AR063724
6 · The paper itself

Abstract

The touch dome (TD) keratinocytes are specialized epidermal cells that intimately associate with the light touch sensing Merkel cells (MCs). The TD keratinocytes function as a niche for the MCs and can induce de novo hair follicles upon stimulation; however, how the TD keratinocytes are maintained during homeostasis remains unclear. scRNA-seq identified a specific TD keratinocyte marker,

Indexed as

KeratinocytesTenascinEpidermisHair FollicleMerkel CellsSkinTenascin

Identifiers

PMID38241368
PMCPMC10798558
OpenAlexW4391019509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.