Evidence map›Paper›PMID 38241160›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2024

Nicotinamide riboside, pterostilbene and ibudilast protect motor neurons and extend survival in ALS mice.

Rafael López-Blanch, Rosario Salvador-Palmer, María Oriol-Caballo, Paz Moreno-Murciano, Ryan W Dellinger, José M Estrela, Elena Obrador

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Rafael López-BlanchDepartment of Physiology, Faculty of Medicine & Odontology, University of Valencia, 46010 Valencia, Spain; Scientia BioTech, 46002 Valencia, Spain.
Rosario Salvador-PalmerDepartment of Physiology, Faculty of Medicine & Odontology, University of Valencia, 46010 Valencia, Spain.
María Oriol-CaballoDepartment of Physiology, Faculty of Medicine & Odontology, University of Valencia, 46010 Valencia, Spain; Scientia BioTech, 46002 Valencia, Spain.
Paz Moreno-MurcianoScientia BioTech, 46002 Valencia, Spain.
Ryan W DellingerElysium Health Inc., New York, NYC 10004, USA.
José M EstrelaDepartment of Physiology, Faculty of Medicine & Odontology, University of Valencia, 46010 Valencia, Spain; Scientia BioTech, 46002 Valencia, Spain; Department of Physiology, Faculty of Pharmacy, University of Valencia, 46100 Burjassot, Spain. Electronic address: jose.m.estrela@uv.es.
Elena ObradorDepartment of Physiology, Faculty of Medicine & Odontology, University of Valencia, 46010 Valencia, Spain; Scientia BioTech, 46002 Valencia, Spain. Electronic address: elena.obrador@uv.es.
Universitat de València · ESElysium Therapeutics (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress and neuroinflammation are major contributors to the pathophysiology of ALS. Nicotinamide riboside (a NAD

Indexed as

Amyotrophic Lateral SclerosisIndolizinesPyrazolesPyridinium CompoundsAnimalsDisease Models, AnimalEndothelial CellsHumansHydrogen PeroxideMiceMice, TransgenicMotor NeuronsNeuroinflammatory DiseasesNiacinamidePilot ProjectsSpinal CordHydrogen PeroxideibudilastIndolizinesNiacinamidenicotinamide-beta-ribosidePyrazolesPyridinium CompoundsSuperoxide DismutaseSuperoxide Dismutase-1Tumor Necrosis Factor-alphaAmyotrophic lateral sclerosisMotor neuronsNAD(+)NeuroinflammationNitric oxideOxidative stress

Identifiers

PMID38241160
PMCPMC10903100
OpenAlexW4389978774

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.