Evidence map›Paper›PMID 38241087›Full record

ReviewDrug delivery2024

Breaking boundaries: the advancements in transdermal delivery of antibiotics.

Ahlam Zaid Alkilani, Rania Hamed, Batool Musleh, Zaina Sharaire

Abstract readReview
In one paragraph

Review in Drug delivery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ahlam Zaid AlkilaniDepartment of Pharmacy, Zarqa University, Zarqa, Jordan.
Rania HamedDepartment of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan.
Batool MuslehDepartment of Pharmacy, Zarqa University, Zarqa, Jordan.
Zaina SharaireDepartment of Pharmacy, Zarqa University, Zarqa, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transdermal drug delivery systems (TDDS) for antibiotics have seen significant advances in recent years that aimed to improve the efficacy and safety of these drugs. TDDS offer many advantages over other conventional delivery systems such as non-invasiveness, controlled-release pattern, avoidance of first-pass metabolism. The objective of this review is to provide an overview on the recent advances in the TDDS of different groups of antibiotics including β-lactams, tetracyclines, macrolides, and lincosamides, utilized for their effective delivery through the skin and to explore the challenges associated with this field. The majority of antibiotics do not have favorable properties for passive transdermal delivery. Thus, novel strategies have been employed to improve the delivery of antibiotics through the skin, such as the use of nanotechnology (nanoparticles, solid-lipid nanoparticles, nanoemulsions, vesicular carriers, and liposomes) or the physical enhancement techniques like microneedles and ultrasound. In conclusion, the transdermal delivery systems could be a promising method for delivering antibiotics that have the potential to improve patient outcomes and enhance the efficacy of drugs. Further research and development are still needed to explore the potential of delivering more antibiotic drugs by using various transdermal drug delivery approaches.

Indexed as

Drug Delivery SystemsSkin AbsorptionAdministration, CutaneousAnti-Bacterial AgentsHumansSkinAnti-Bacterial Agentsantibioticsbeta-lactamsdrug deliverylincosamidesmacrolidestetracyclinesTransdermal

Identifiers

PMID38241087
PMCPMC10802811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.