Evidence map›Paper›PMID 38240846›Full record

ArticleApplied microbiology and biotechnology2024

New biomarkers underlying acetic acid tolerance in the probiotic yeast Saccharomyces cerevisiae var. boulardii.

Wiwan Samakkarn, Paul Vandecruys, Maria Remedios Foulquié Moreno, Johan Thevelein, Khanok Ratanakhanokchai, Nitnipa Soontorngun

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Wiwan SamakkarnExcellent Research Laboratory for Yeast Innovation, Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Paul VandecruysLaboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven, Heverlee, Belgium.
Maria Remedios Foulquié MorenoLaboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven, Heverlee, Belgium.
Johan TheveleinLaboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven, Heverlee, Belgium.
Khanok RatanakhanokchaiExcellent Research Laboratory for Yeast Innovation, Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Nitnipa SoontorngunExcellent Research Laboratory for Yeast Innovation, Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand. nitnipa.soo@kmutt.ac.th.ORCID http://orcid.org/0000-0003-4143-4780
King Mongkut's University of Technology Thonburi · THVIB-KU Leuven Center for Microbiology · BEErasmus Hospital · BE

Funding

King Mongkut's University of Technology Thonburi 6620353King Mongkut's University of Technology Thonburi 6620864Thailand International Cooperation Agency PHD/0189/2558Thailand Science Research and Innovation 6620353
6 · The paper itself

Abstract

Evolutionary engineering experiments, in combination with omics technologies, revealed genetic markers underpinning the molecular mechanisms behind acetic acid stress tolerance in the probiotic yeast Saccharomyces cerevisiae var. boulardii. Here, compared to the ancestral Ent strain, evolved yeast strains could quickly adapt to high acetic acid levels (7 g/L) and displayed a shorter lag phase of growth. Bioinformatic-aided whole-genome sequencing identified genetic changes associated with enhanced strain robustness to acetic acid: a duplicated sequence in the essential endocytotic PAN1 gene, mutations in a cell wall mannoprotein (dan4

Indexed as

ProbioticsSaccharomyces boulardiiSaccharomyces cerevisiae ProteinsAcetic AcidBiomarkersDNA-Binding ProteinsSaccharomyces cerevisiaeTranscription FactorsAcetic AcidBiomarkersDNA-Binding ProteinsOAF1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsAcetic acid toleranceFood and alcohol fermentationMicrobial stress responseOmic analysisProbioticsSaccharomyces cerevisiae var. boulardii

Identifiers

PMID38240846
PMCPMC10799125
OpenAlexW4391030311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.