SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024
Prevalence and unfavorable outcome of frailty in older adults with gastric cancer: a systematic review and meta-analysis.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Risk factors for preoperative frailty in older patients with gastric cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Preoperative short physical performance battery in older adult patients with gastric cancer is associated with postoperative complications.Aging clinical and experimental research · 2026Article
- Assessment of Frailty in Hospitalized Cancer Patients: A Psychometric Study of the Brazilian Version of Kihon Checklist.Revista brasileira de enfermagem · 2026Article
- Impact of Abdominal Aortic Calcification on Long-Term Outcome after Gastric Cancer Surgery: a Retrospective Study.Journal of gastrointestinal cancer · 2025Article
- Eligibility criteria in phase 3 randomized controlled trials in gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025Article
- Implementation and Outcomes of a Perioperative Geriatrics Strategy, PRIME, for Older Adults Undergoing Gastrointestinal Cancer Surgery.Current oncology (Toronto, Ont.) · 2025Article
- Analysis of frailty change trajectories and its risk factors in patients with gastrointestinal tumor surgery: a prospective observational longitudinal study.World journal of surgical oncology · 2025Observational
- OTX2 expression contributes progression of gastric cancer in young adults.Scientific reports · 2025Article
- Development and validation of a machine learning model to predict postoperative complications following radical gastrectomy for gastric cancer.Frontiers in oncology · 2025Article
- The association between family health and frailty in preoperative patients with gastric cancers: the mediating role of health literacy and physical activity.Frontiers in public health · 2025Article
- Incidence and influencing factors of postoperative frailty in elderly prostate cancer patients: a cross-sectional study.Frontiers in medicine · 2025Article
- Effects of frailty on patients with oral and maxillofacial space infection: a retrospective analysis.BMC oral health · 2024Article
- Knowledge mapping of frailty and surgery: a bibliometric and visualized analysis.Langenbeck's archives of surgery · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimPrevious studies reported inconsistent results on the prevalence and prognostic implications of frailty among older adults with gastric cancer. This systematic review synthesized available literature pertaining on this topic to establish the prevalence and unfavorable outcomes of frailty in older adults with gastric cancer.
methodsA comprehensive search was conducted across multiple English databases including PubMed, Cochrane Library, CINAHL, Embase, and Web of Science as well as Chinese databases, namely, CNKI, Wan Fang, and CBM, from inception to July 4, 2023, to identify potential studies. Data related to the incidence of frailty and its unfavorable outcomes in older adults with gastric cancer were extracted. RevMan5.3 and R 4.2.2 were used to evaluate pooled prevalence, hazard ratios (HR), and 95% confidence interval (CI).
resultsThis review comprehensively selected 13 studies, comprising 9 cohort studies and 4 cross-sectional studies, on 44,117 older adults diagnosed with gastric cancer. The incidence of frailty among older adults with gastric cancer ranged from 10 to 71%. The pooled prevalence of frailty was 29% (95% CI 0.21-0.39). Frailty was found to be associated with an elevated risk of postoperative complications (HR = 1.99, 95% CI 1.45-2.73), prolonged postoperative hospital stay (HR = 2.68, 95% CI 2.38-3.02), likelihood of readmission (HR = 3.28, 95% CI 1.77-6.08), and an increased mortality risk (HR = 1.60, 95% CI 1.36-1.90).
conclusionsFrailty was associated with a poor prognosis in older adults with gastric cancer. Clinical medical staff should focus on the frailty of older adults with gastric cancer, conduct large-scale, multicenter, and prospective studies and early screening of patients, and provide guidance for the implementation of prevention and treatment strategies.
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