Evidence map›Paper›PMID 38240815›Full record

ArticleInnere Medizin (Heidelberg, Germany)2024

[Unexplained reduction in the general condition of a female lung cancer patient].

J Brägelmann, S Becker, D Stenzel, A Budahn

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Innere Medizin (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

J BrägelmannKlinik für Endokrinologie, Diabetologie und Stoffwechsel, Universitätsmedizin Essen, Hufelandstraße 55, 45147, Essen, Deutschland. Johannasibylle.braegelmann@uk-essen.de.
S BeckerMarienhaus Klinikum Mainz, Mainz, Deutschland.
D StenzelMarienhaus Klinikum Mainz, Mainz, Deutschland.
A BudahnMarienhaus Klinikum Mainz, Mainz, Deutschland.
Kliniken Essen-Mitte · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 63-year-old female patient with lung cancer presented to our emergency room for the first time with a sudden reduction in general condition, vomiting and severe weakness. She stated that she was receiving chemotherapy for the lung cancer and reported that she had no other relevant previous illnesses. Our initial suspected diagnosis was cytostatic-induced nausea and vomiting. Contrary to this suspected diagnosis, diagnostics carried out in the emergency room revealed the findings of ketoacidosis on the basis of an initial manifestation of diabetes mellitus with hyperglycemic decompensation as well as severe, manifest hypothyroidism. After obtaining the preliminary findings, it became evident that the patient was not receiving chemotherapy, but rather immune checkpoint therapy using durvalumab. The initial manifestations described were therefore to be viewed as immune reactions associated with durvalumab. After initiating diabetic recompensation therapy and substitution with L‑thyroxine, a rapid improvement in the patient's general condition was achieved.

Indexed as

Lung NeoplasmsAntibodies, MonoclonalDiagnosis, DifferentialFemaleHumansHypothyroidismMiddle AgedThyroxineAntibodies, MonoclonaldurvalumabThyroxineCheckpoint inhibitor associated autoimmune diabetes mellitus (CIADM)DurvalumabElectronic patient file (epf)Immune-Related Adverse Events (irAEs)Information infrastructure

Identifiers

PMID38240815
PMCPMC11136821
OpenAlexW4391023827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.