ArticleAnnals of the New York Academy of Sciences2024
Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids.
Article in Annals of the New York Academy of Sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Article
- Sexually dimorphic control of aggression by androgen signaling in a cichlid.Molecular and cellular endocrinology · 2024Article
- Androgen receptor alpha deficiency impacts aromatase expression in the female cichlid brain.Royal Society open science · 2024Article
- Sexually dimorphic control of aggression by androgen signaling in a cichlid.bioRxiv : the preprint server for biology · 2024Article
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2 authors at 1 institution in 1 country.
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Abstract
Social behaviors are regulated by sex steroid hormones, such as androgens and estrogens. However, the specific molecular and neural processes modulated by steroid hormones to generate social behaviors remain to be elucidated. We investigated whether some actions of androgen signaling in the control of social behavior may occur through the regulation of estradiol synthesis in the highly social cichlid fish, Astatotilapia burtoni. Specifically, we examined the expression of cyp19a1, a brain-specific aromatase, in the brains of male A. burtoni lacking a functional ARα gene (ar1), which was recently found to be necessary for aggression in this species. We found that cyp19a1 expression is higher in wild-type males compared to ar1 mutant males in the anterior tuberal nucleus (ATn), the putative fish homolog of the mammalian ventromedial hypothalamus, a brain region that is critical for aggression across taxa. Using in situ hybridization chain reaction, we determined that cyp19a1
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