ArticleHypertension (Dallas, Tex. : 1979)2024
Role of the CCL5 and Its Receptor, CCR5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage.
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Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
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27 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
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- GENETIC AND PHARMACOLOGIC ACTIVATION OF BECLIN1 PREVENTS ALDOSTERONE-INDUCED CARDIOVASCULAR DAMAGE.bioRxiv : the preprint server for biology · 2026Article
- CCR5/CCL5-Dependent Mitochondrial Dysfunction Contributes to Angiotensin II-Induced Vascular Impairment in Mice.bioRxiv : the preprint server for biology · 2026Article
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- Emerging roles for endothelial mineralocorticoid receptor in disease pathogenesis: potential new indications for mineralocorticoid receptor antagonism.Current opinion in physiology · 2026Article
- Nox1-Derived ROS Amplifies Calcium Entry and Enhances Pneumolysin-Induced Lung Endothelial Barrier Dysfunction in Hyperglycemia.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- Mechanisms of transcriptional regulation of CCR5, which is the co-receptor for R5-tropic HIV and is also involved in other disease processes.Biochemical Society transactions · 2026Review
- CCL5 promotes angiotensin II-induced cardiac remodeling through regulation of platelet-driven M2 macrophage polarization.Theranostics · 2026Article
- Targeting vascular inflammation and endothelial dysfunction with nanobodies: emerging therapeutic strategies for cardiovascular disease.Frontiers in immunology · 2026Review
- The Role of the CCR5 Receptor in Neuropathic Pain Modulation: Current Insights and Therapeutic Implications.Biomedicines · 2025Review
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025Review
- Chemokine receptors in vascular biology: a review of current evidence, implications, and therapeutic targets for hypertension.Clinical science (London, England : 1979) · 2025Review
- Uncovering immune pathways for therapeutic targeting of hypertension.Expert opinion on therapeutic targets · 2025Review
- C-C chemokine ligand 5 from women subcutaneous adipose tissue has a central role in vascular aging.Cardiovascular diabetology · 2025Article
- Concomitant Diabetes and Atrial Fibrillation: Epicardial Fat and Macrophage-Related Mechanisms.Diabetes/metabolism research and reviews · 2025Review
- Biomarkers for Predicting Blood Pressure Response to Renal Denervation.Current hypertension reports · 2025Review
- Enhancing Endothelial Differentiation of Mesenchymal Stem Cells Derived from Human Turbinates Using Lab-on-a-Chip Technology.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
Rafael M CostaDepartment of Pediatrics at University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, (R.M.C., D.M.C., A.B.-N., J.V.A., W.M.C.A., S.S., J.H., T.B.-N.), University of Pittsburgh, PA.
Débora M CerqueiraDepartment of Pediatrics at University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, (R.M.C., D.M.C., A.B.-N., J.V.A., W.M.C.A., S.S., J.H., T.B.-N.), University of Pittsburgh, PA.
Ariane Bruder-NascimentoDepartment of Pediatrics at University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, (R.M.C., D.M.C., A.B.-N., J.V.A., W.M.C.A., S.S., J.H., T.B.-N.), University of Pittsburgh, PA.
Juliano V AlvesDepartment of Pediatrics at University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, (R.M.C., D.M.C., A.B.-N., J.V.A., W.M.C.A., S.S., J.H., T.B.-N.), University of Pittsburgh, PA.
Wanessa M C AwataDepartment of Pediatrics at University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, (R.M.C., D.M.C., A.B.-N., J.V.A., W.M.C.A., S.S., J.H., T.B.-N.), University of Pittsburgh, PA.ORCID 0000-0002-8925-9929
Shubhnita SinghDepartment of Pediatrics at University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, (R.M.C., D.M.C., A.B.-N., J.V.A., W.M.C.A., S.S., J.H., T.B.-N.), University of Pittsburgh, PA.ORCID 0000-0002-1835-2317
Alexander KufnerVascular Medicine Institute (A.K., E.J., E.C.-P., P.D., P.J.P., T.B.-N.), University of Pittsburgh, PA.ORCID 0009-0005-3127-7998
Douglas S PradoDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA (D.S.P., W.F.H., P.D.), University of Pittsburgh, PA.ORCID 0000-0003-4594-1851
Ebin JohnyVascular Medicine Institute (A.K., E.J., E.C.-P., P.D., P.J.P., T.B.-N.), University of Pittsburgh, PA.ORCID 0000-0002-8857-9357
Eugenia Cifuentes-PaganoVascular Medicine Institute (A.K., E.J., E.C.-P., P.D., P.J.P., T.B.-N.), University of Pittsburgh, PA.ORCID 0000-0002-2482-080X
William F HawseDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA (D.S.P., W.F.H., P.D.), University of Pittsburgh, PA.ORCID 0000-0001-8371-3345
Partha DuttaVascular Medicine Institute (A.K., E.J., E.C.-P., P.D., P.J.P., T.B.-N.), University of Pittsburgh, PA.ORCID 0000-0001-7456-1757
Patrick J PaganoVascular Medicine Institute (A.K., E.J., E.C.-P., P.D., P.J.P., T.B.-N.), University of Pittsburgh, PA.ORCID 0000-0002-7475-808X
Jacqueline HoDepartment of Pediatrics at University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, (R.M.C., D.M.C., A.B.-N., J.V.A., W.M.C.A., S.S., J.H., T.B.-N.), University of Pittsburgh, PA.
Thiago Bruder-NascimentoDepartment of Pediatrics at University of Pittsburgh Medical Center (UPMC) Children's Hospital of Pittsburgh, (R.M.C., D.M.C., A.B.-N., J.V.A., W.M.C.A., S.S., J.H., T.B.-N.), University of Pittsburgh, PA.ORCID 0000-0001-5671-318X
University of Pittsburgh · USChildren's Hospital of Pittsburgh · USUniversidade de Ribeirão Preto · BR
Funding
Mechanisms of Myocardial Infarction-induced insulin resistanceR01HL143967 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUTTA, PARTHA · 2018 to 2022
$2.6MCardioprotective role of Humanin in agingR01AG069399 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUTTA, PARTHA, MUZUMDAR, RADHIKA HIREN · 2021 to 2025
$2.3MProgressive degenerative role of Nox and thrombospondin-1 in the aging vasculatureR01HL142248 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 2019 to 2022
$2.3MThe role of microglia Nek6 in myocardial infarction-induced cognitive impairmentR01HL142629 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUTTA, PARTHA · 2020 to 2023
$2.3MDicarboxylic acid therapy for prevention of kidney injuryR01DK134346 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERIC S GOETZMAN, Sunder Sims-Lucas · 2024 to 2026
$1.9MDefining how phospholipid signaling networks control Th17 differentiation and effector functionR01AI175111 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Francis Hawse · 2024 to 2026
$1.9MThe role of SerpinB2 in insulin resistance and inflammationR01DK129339 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUTTA, PARTHA · 2022 to 2025
$1.7MTSP-1 and ROS: CD47 and SIRP-alpha as Mediators of Vascular DysfunctionR01HL112914 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ISENBERG, JEFFREY S, PAGANO, PATRICK J · 2013 to 2016
$1.7MEndothelial miR-17~92 protects against acute kidney injuryR01DK125015 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE, SIMS-LUCAS, SUNDER · 2020 to 2023
$1.5MRegulation of tubulointerstitial crosstalk by microRNAs in renal fibrosisR01DK137410 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2023 to 2025
$936kLeptin, a therapeutic avenue for the treatment of vascular disease, focus on congenital and antiretroviral therapy-associated lipodystrophiesR00HL140139 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRUDER, THIAGO · 2019 to 2021
$733kNHLBI NIH HHS R00 HL140139NHLBI NIH HHS R01 HL142248NHLBI NIH HHS R01 HL142629NHLBI NIH HHS R01 HL143967NIAID NIH HHS R01 AI175111NIA NIH HHS R01 AG069399NIDDK NIH HHS R01 DK125015NIDDK NIH HHS R01 DK129339NIDDK NIH HHS R01 DK134346NIDDK NIH HHS R01 DK137410
Abstract
backgroundAldosterone has been described to initiate cardiovascular diseases by triggering exacerbated sterile vascular inflammation. The functions of CCL5 (C-C motif chemokine ligand 5) and its receptor CCR5 (C-C motif chemokine receptor 5) are well known in infectious diseases, their contributions to aldosterone-induced vascular injury and hypertension remain unknown.
methodsWe analyzed the vascular profile, blood pressure, and renal damage in wild-type (CCR5
resultsAldosterone treatment resulted in exaggerated CCL5 circulating levels and vascular CCR5 expression in CCR5
conclusionsOur data demonstrate that CCL5/CCR5, through activation of NFκB and NOX1, is critically involved in aldosterone-induced vascular and renal damage and hypertension placing CCL5 and CCR5 as potential therapeutic targets for conditions characterized by aldosterone excess.
Indexed as
AldosteroneChemokine CCL5HypertensionReceptors, CCR5AnimalsEndothelial CellsInflammationMiceAldosteroneCcl5 protein, mouseCCR5 protein, mouseChemokine CCL5Receptors, CCR5aldosteronechemokineschemokines receptorsNADPH oxidasesoxidative stress
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