Evidence map›Paper›PMID 38239833›Full record

ReviewFrontiers in neuroscience2023

Simple models to understand complex disease: 10 years of progress from

Randall J Eck, Jade G Stair, Brian C Kraemer, Nicole F Liachko

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Frontiers in aging neuroscience · 2026
    Review
  2. Review
  3. Unraveling Molecular Targets for Neurodegenerative Diseases ThroughInternational journal of molecular sciences · 2025
    Review
  4. Studying the mechanisms of neurodegeneration:Frontiers in cellular neuroscience · 2025
    Review
  5. Review
  6. Animal Models of Human Disease 2.0.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Randall J Eck *Graduate Program in Neuroscience, University of Washington, Seattle, WA, United States.
Jade G Stair *Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States.
Brian C KraemerDivision of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, United States.
Nicole F LiachkoDivision of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, United States.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Training in Cellular & Molecular BiologyT32GM136534 · NIGMS · UNIVERSITY OF WASHINGTON · PI Andrew Atwell Oberst, LARRY S ZWEIFEL · 2021 to 2026
$5.8M
Developing Neuroprotective Strategies for Tau and TDP-43 Proteinopathy in FTLDR01NS064131 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI KRAEMER, BRIAN C. · 2009 to 2022
$5.0M
MSUT2 modulates pathological tau in AD and model organismsRF1AG055474 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI KRAEMER, BRIAN C. · 2017 to 2017
$3.2M
TDP-43 in Alzheimer's diseaseR01AG066729 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI LIACHKO, NICOLE FARON · 2021 to 2025
$2.6M
SPOP drives neurodegenerative tauopathyRF1AG078374 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI KRAEMER, BRIAN C. · 2023 to 2023
$1.8M
SPOP modifies neurodegenerative proteinopathy in Alzheimer’s Disease.F31AG082391 · NIA · UNIVERSITY OF WASHINGTON · PI ECK, RANDALL · 2023 to 2023
$48k
BLRD VA I01 BX002619BLRD VA I01 BX004044BLRD VA I01 BX005762BLRD VA IK6 BX006467NIA NIH HHS F31 AG082391NIA NIH HHS R01 AG066729NIA NIH HHS RF1 AG055474NIA NIH HHS RF1 AG078374NIGMS NIH HHS T32 GM136534NIH HHS P40 OD010440NINDS NIH HHS R01 NS064131
6 · The paper itself

Abstract

The nematode

Indexed as

amyotrophic lateral sclerosisC9orf72C. elegansfrontotemporal lobar degenerationFUSneurodegenerationSOD1TDP-43

Identifiers

PMID38239833
PMCPMC10794587

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.