Evidence map›Paper›PMID 38239650›Full record

ArticleFrontiers in oncology2023

Case report:

Marwah Al-Aloosi, Amanda M Prechtl, Payel Chatterjee, Brady Bernard, Christopher J Kemp, Rachele Rosati, Robert L Diaz, Lauren R Appleyard, Shalini Pereira, Alex Rajewski and 3 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Marwah Al-AloosiSEngine Precision Medicine, Seattle, WA, United States.
Amanda M PrechtlSEngine Precision Medicine, Seattle, WA, United States.
Payel ChatterjeeSEngine Precision Medicine, Seattle, WA, United States.
Brady BernardSEngine Precision Medicine, Seattle, WA, United States.
Christopher J KempDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, United States.
Rachele RosatiSEngine Precision Medicine, Seattle, WA, United States.
Robert L DiazSEngine Precision Medicine, Seattle, WA, United States.
Lauren R AppleyardSEngine Precision Medicine, Seattle, WA, United States.
Shalini PereiraSEngine Precision Medicine, Seattle, WA, United States.
Alex RajewskiSEngine Precision Medicine, Seattle, WA, United States.
Amber McDonaldPrivate Health Management, Los Angeles, CA, United States.
Eva J GordonPrivate Health Management, Los Angeles, CA, United States.
Carla GrandoriSEngine Precision Medicine, Seattle, WA, United States.
Precision for Medicine (United States) · USFred Hutch Cancer Center · US

Funding

Personalized cancer models to discover and develop new therapeutic targets.U01CA217883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KEMP, CHRISTOPHER J · 2017 to 2021
$4.3M
A Patient-Centric Approach to Advance Functional Precision OncologyU01CA282109 · NCI · FRED HUTCHINSON CANCER CENTER · PI CHRISTOPHER J KEMP · 2023 to 2026
$4.2M
An Academic-Industry Partnership to Advance Functional Genomics for Personalized Oncology.R01CA214428 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KEMP, CHRISTOPHER J · 2018 to 2022
$3.0M
NCI NIH HHS R01 CA214428NCI NIH HHS U01 CA217883NCI NIH HHS U01 CA282109
6 · The paper itself

Abstract

Patients presenting with stage 4 ovarian carcinoma, including low-grade serous disease, have a poor prognosis. Although platinum-based therapies can offer some response, these therapies are associated with many side effects, and treatment resistance often develops. Toxic side effects along with disease progression render patients unable to receive additional lines of treatment and limit their options to hospice or palliative care. In this case report, we describe a patient with an unusual case of metastatic low-grade serous ovarian cancer with some features of high-grade disease who had received four previous lines of treatment and was suffering from atelectasis, pulmonary embolism, and hydronephrosis. A CLIA-certified drug sensitivity assay of an organoid culture derived from the patient's tumor (PARIS

Indexed as

everolimusfulvestrantfunctional precision medicinelow grade serous ovarian cancermedium-throughput drug screentumor organoids

Identifiers

PMID38239650
PMCPMC10794297
OpenAlexW4390585473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.