Evidence map›Paper›PMID 38239107›Full record

ArticleThe Journal of organic chemistry2024

Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides.

Sandra E Gatarz, Oliver M Griffiths, Henrique A Esteves, Wenhua Jiao, Peter Morse, Ethan L Fisher, David C Blakemore, Steven V Ley

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sandra E GatarzYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Oliver M GriffithsYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0003-3954-9343
Henrique A EstevesYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Wenhua JiaoYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Peter MorseMedicine Design, Pfizer, Inc., Groton, Connecticut 06340, United States.
Ethan L FisherMedicine Design, Pfizer, Inc., Groton, Connecticut 06340, United States.ORCID 0000-0002-8700-5108
David C BlakemoreMedicine Design, Pfizer, Inc., Groton, Connecticut 06340, United States.
Steven V LeyYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0002-7816-0042
University of Cambridge · GBPfizer (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A method to assemble (hetero)aryl sulfonamides via the reductive coupling of aryl sulfinates and nitroarenes is reported. Various reducing conditions with sodium bisulfite and with or without tin(II) chloride in DMSO were developed using an ultrasound bath to improve reaction homogeneity and mixing. A range of (hetero)aryl sulfonamides bearing a selection of functional groups were prepared, and the mechanism of the transformation was investigated. These investigations have led us to propose the formation of nitrosoarene intermediates, which were established via an independent molecular coupling strategy.

Identifiers

PMID38239107
PMCPMC10845164
OpenAlexW4391030626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.