Evidence map›Paper›PMID 38238748›Full record

ArticleJournal of nanobiotechnology2024

Asymmetric adhesive SIS-based wound dressings for therapeutically targeting wound repair.

Wende Yao, Zelong Song, Xiaodong Ma, Yiqian Huang, Xueying Zhang, Yunhuan Li, Pengfei Wei, Julei Zhang, Chenlu Xiong, Sihan Yang and 5 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wende Yao *School of Medicine, Nankai University, Tianjin, 300071, China.
Zelong Song *School of Medicine, Nankai University, Tianjin, 300071, China.
Xiaodong Ma *Department of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100048, China.
Yiqian HuangBeijing Biosis Healing Biological Technology Co., Ltd, Beijing, 102600, China.
Xueying ZhangBeijing Biosis Healing Biological Technology Co., Ltd, Beijing, 102600, China.
Yunhuan LiBeijing Biosis Healing Biological Technology Co., Ltd, Beijing, 102600, China.
Pengfei WeiBeijing Biosis Healing Biological Technology Co., Ltd, Beijing, 102600, China.
Julei ZhangDepartment of Plastic and Reconstructive Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China.
Chenlu XiongSchool of Medicine, Nankai University, Tianjin, 300071, China.
Sihan YangSchool of Medicine, Nankai University, Tianjin, 300071, China.
Yujian XuDepartment of Plastic and Reconstructive Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China.
Wei JingBeijing Biosis Healing Biological Technology Co., Ltd, Beijing, 102600, China.
Bo ZhaoBeijing Biosis Healing Biological Technology Co., Ltd, Beijing, 102600, China. zhaobo@biosishealing.com.
Xuesong ZhangSchool of Medicine, Nankai University, Tianjin, 300071, China. zhangxuesong301@126.com.
Yan HanSchool of Medicine, Nankai University, Tianjin, 300071, China. 13720086335@163.com.

Funding

National Natural Science Foundation of China 82102342Natural Science Foundation of Hebei Province H2020505007
6 · The paper itself

Abstract

Severe tissue injuries pose a significant risk to human health. Conventional wound dressings fall short in achieving effective tissue regeneration, resulting in suboptimal postoperative healing outcomes. In this study, an asymmetric adhesive wound dressing (marked as SIS/PAA/LAP) was developed, originating from acrylate acid (AA) solution with laponite (LAP) nanoparticles polymerization and photo-crosslinked on the decellularized extracellular matrix small intestinal submucosa (SIS) patch. Extensive studies demonstrated that the SIS/PAA/LAP exhibited higher tissue adhesion strength (~ 33 kPa) and burst strength (~ 22 kPa) compared to conventional wound dressings like Tegaderm and tissue adhesive products. Importantly, it maintained favorable cell viability and demonstrated robust angiogenic capacity. In animal models of full-thickness skin injuries in rats and skin injuries in Bama miniature pigs, the SIS/PAA/LAP could be precisely applied to wound sites. By accelerating the formation of tissue vascularization, it displayed superior tissue repair outcomes. This asymmetrically adhesive SIS-based patch would hold promising applications in the field of wound dressings.

Indexed as

AdhesivesWound HealingAnimalsBandagesHumansRatsSkinSwineAdhesivesAsymmetric compositeSISTissue regenerationVascularizationWound dressing

Identifiers

PMID38238748
PMCPMC10797997

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.