ArticleBMC geriatrics2024
The association between sarcopenia and incident of depressive symptoms: a prospective cohort study.
Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Changes in Sarcopenia and Incident Depression in Prospective Cohorts.Journal of clinical medicine · 2026Article
- Sarcopenia Severity and the Accumulation of Geriatric Syndromes Among Older Adults: A Cross-Sectional Study from Vietnam.Geriatrics (Basel, Switzerland) · 2026Article
- Association between low muscle mass and depression in South Korean adults.BMC psychiatry · 2026Article
- Sarcopenia and depression: a strong association in older adults with type 2 diabetes in Vietnam.BMC geriatrics · 2026Article
- Association of the sarcopenia index with incident depressive symptoms and adverse depressive symptom trajectories.Frontiers in nutrition · 2026Article
- Brain-bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Correlation analysis between sleep quality and depressive symptoms among rural elderly in China: An observational study.World journal of psychiatry · 2025Article
- Associations of sarcopenia with depression and suicidal ideation: the sex-specific mediating role of loneliness.BMC geriatrics · 2025Article
- Comparison of depression risk and depression-related ambulatory care utilization in sarcopenia patients with and without Chinese herbal medicine.World journal of psychiatry · 2025Article
- Prediction model for depression risk in middle-aged and elderly patients with metabolic syndrome: a nomogram and interpretable machine learning approach based on CHARLS.BMC psychiatry · 2025Article
- Improved Strength Prediction Combining MRI Biomarkers of Muscle Quantity and Quality.NMR in biomedicine · 2025Article
- Sarcopenia in chronic obstructive pulmonary disease: mechanisms, diagnosis, and management strategies.Annals of medicine and surgery (2012) · 2025Review
- Mediating role of SII in the association between LC9 and overactive bladder.Scientific reports · 2025Article
- A Comprehensive Review of the Correlations of Measurement Parameters among Modern Technologies for Sarcopenia Assessment.Aging and disease · 2025Review
- Patient-reported outcomes in sarcopenia: An ICFSR task force report.The Journal of frailty & aging · 2025Review
- Integrative approaches to depression in end-stage renal disease: insights into mechanisms, impacts, and pharmacological strategies.Frontiers in pharmacology · 2025Review
- High Prevalence and Clinical Correlates of Sarcopenia and Metabolic Syndrome in Outpatients with Major Depressive Disorder: A Cross-Sectional Study.Neuropsychiatric disease and treatment · 2025Article
- Article
- Connecting the dots: sex, depression, and musculoskeletal health.The Journal of clinical investigation · 2024Review
- Association of Sarcopenia and Its Components with Depression Symptoms in Older Patients with Stroke.Annals of geriatric medicine and research · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundEpidemiological studies have shown that sarcopenia was associated with depression among older adults. However, most of these investigations used a cross-sectional design, limiting the ability to establish a causal relation, the present study examined whether sarcopenia was associated with incident depressive symptoms.
methodsThis is a prospective cohort study with participants from the Western China Health and Aging Trends (WCHAT) study. Participants could complete anthropometric measurements and questionnaires were included. The exposure was sarcopenia, defined according to the Asian Working Group for Sarcopenia in 2019, the outcome was depressive symptoms, evaluated by GDS-15. We excluded depression and depressive symptoms at baseline and calculated the risk of incident depressive symptoms during the follow-up year.
resultsA total of 2612 participants (mean age of 62.14 ± 8.08 years) were included, of which 493 with sarcopenia. 78 (15.82%) participants with sarcopenia had onset depressive symptoms within the next year. After multivariable adjustment, sarcopenia increased the risk of depressive symptoms (RR = 1.651, 95%CI = 1.087-2.507, P = 0.0187) in overall participants. Such relationship still exists in gender and sarcopenia severity subgroups. Low muscle mass increased the risk of depressive symptoms (RR = 1.600, 95%CI = 1.150-2.228, P = 0.0053), but low muscle strength had no effect (RR = 1.250, 95%CI = 0.946-1.653, P = 0.117).
conclusionsSarcopenia is an independent risk factor for depressive symptoms, Precautions to early detect and targeted intervene for sarcopenia should continue to be employed in adult with sarcopenia to achieve early prevention for depression and reduce the incidence of adverse clinical outcomes.
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