Evidence map›Paper›PMID 38238608›Full record

ArticleNature immunology2024

The transcriptional cofactor Tle3 reciprocally controls effector and central memory CD8

Xin Zhao, Wei Hu, Sung Rye Park, Shaoqi Zhu, Shengen Shawn Hu, Chongzhi Zang, Weiqun Peng, Qiang Shan, Hai-Hui Xue

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. The role of CD8Frontiers in immunology · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. TRIM56 Promotes White Adipose Tissue Browning to Attenuate Obesity by Degrading TLE3.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Article
  13. Article
  14. Releasing the TLE3 break to put TNature immunology · 2024
    Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Xin Zhao *Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Wei Hu *Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Sung Rye Park *Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Shaoqi Zhu *Department of Physics, The George Washington University, Washington, DC, USA.
Shengen Shawn HuCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-9691-7344
Chongzhi ZangCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0003-4812-3627
Weiqun PengDepartment of Physics, The George Washington University, Washington, DC, USA.ORCID http://orcid.org/0000-0001-5521-9091
Qiang ShanNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China. shanq2009@gmail.com.ORCID http://orcid.org/0000-0002-7089-0278
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA. haihui.xue@hmh-cdi.org.ORCID http://orcid.org/0000-0002-9163-7669
Hackensack University Medical Center · USGeorge Washington University · USUniversity of Virginia · USChinese Academy of Medical Sciences & Peking Union Medical College · CNVA New Jersey Health Care System · US

Funding

Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Ezh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4M
Modulating costimulation pathways to improve follicular helper T cell and antibody responsesI01BX005771 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI XUE, HAI-HUI · 2022 to 2025
–
BLRD VA I01 BX005771NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874
6 · The paper itself

Abstract

Antigen-experienced CD8

Indexed as

CD8-Positive T-LymphocytesMemory T CellsCell DifferentiationImmunologic MemoryTranscription FactorsTranscription Factors

Identifiers

PMID38238608
PMCPMC10916363
OpenAlexW4390975970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.