Evidence map›Paper›PMID 38238480›Full record

ArticleNature biotechnology2024

KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.

Tong Wu, Anthony Youzhi Cheng, Yuexiu Zhang, Jiayu Xu, Jinjun Wu, Li Wen, Xiao Li, Bei Liu, Xiaoyang Dou, Pingluan Wang and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Nature biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Ancestral intronic splicing regulatory elements in the SCNbioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Tong Wu *Department of Chemistry, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-9968-9909
Anthony Youzhi Cheng *Department of Genetics and Genome Sciences and Institute for Systems Genomics, University of Connecticut, Farmington, CT, USA.
Yuexiu ZhangDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Jiayu XuDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Jinjun WuDepartment of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2379-1162
Li WenDepartment of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.
Xiao LiDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Bei LiuDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Xiaoyang DouDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Pingluan WangDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Linda ZhangDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Jingyi FeiDepartment of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-9775-3820
Jianrong LiDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Zhengqing OuyangDepartment of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA. ouyang@schoolph.umass.edu.ORCID http://orcid.org/0000-0003-2842-8503
Chuan HeDepartment of Chemistry, University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.ORCID http://orcid.org/0000-0003-4319-7424
Howard Hughes Medical Institute · USThe Ohio State University · USUniversity of Chicago · USAgency for Science, Technology and Research · SGUniversity of Massachusetts Amherst · US

Funding

Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
RNA STRUCTUROME IN POST-TRANSCRIPTIONAL REGULATIONR35GM124998 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Zhengqing Ouyang · 2017 to 2026
$2.8M
Targets and functions of the mammalian snoRNAomeR01HG012780 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN, PAN, TAO · 2022 to 2025
$2.8M
NHGRI NIH HHS R01 HG012780NHGRI NIH HHS RM1 HG008935NIGMS NIH HHS R35 GM124998U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) R01HG012780U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) RM1HG008935U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM124998
6 · The paper itself

Abstract

RNA fate and function are affected by their structures and interactomes. However, how RNA and RNA-binding proteins (RBPs) assemble into higher-order structures and how RNA molecules may interact with each other to facilitate functions remain largely unknown. Here we present KARR-seq, which uses N

Indexed as

Nucleic Acid ConformationRNA, ViralHumansRespiratory Syncytial VirusesRNARNA-Binding ProteinsRNA, MessengerVesiculovirusVirus ReplicationRNARNA-Binding ProteinsRNA, MessengerRNA, Viral

Identifiers

PMID38238480
PMCPMC11255127
OpenAlexW4390971893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.