Evidence map›Paper›PMID 38238420›Full record

ArticleCommunications chemistry2024

Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2.

Francisco J Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan J Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr and 8 more

Abstract read
In one paragraph

Article in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The pivotal role of β-lactone stereochemistry in the development of SARS-CoV-2 MProtein science : a publication of the Protein Society · 2026
    Article
  2. Review
  3. A SARS-CoV-2 MNature communications · 2025
    Article
  4. Covalent chemical probes.Communications chemistry · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Francisco J MedranoCentro de Investigaciones Biológicas Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, Spain. fjmedrano@cib.csic.es.ORCID http://orcid.org/0000-0002-8185-9751
Sergio de la Hoz-RodríguezDepartament de Química Inorgànica i Orgànica, Universitat Jaume I, 12071, Castelló, Spain.ORCID http://orcid.org/0000-0002-1087-7143
Sergio MartíDepartament de Química Física i Analítica, Universitat Jaume I, 12071, Castelló, Spain.
Kemel ArafetDepartament de Química Física i Analítica, Universitat Jaume I, 12071, Castelló, Spain.
Tanja SchirmeisterInstitute of Pharmaceutical and BiomedicalSciences, Johannes Gutenberg-University Mainz, Staudinger Weg 5, 55128, Mainz, Germany.
Stefan J HammerschmidtInstitute of Pharmaceutical and BiomedicalSciences, Johannes Gutenberg-University Mainz, Staudinger Weg 5, 55128, Mainz, Germany.ORCID http://orcid.org/0000-0002-0769-8435
Christin MüllerInstitute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.ORCID http://orcid.org/0000-0002-6444-9478
Águeda González-MartínezCentro de Investigaciones Biológicas Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, Spain.
Elena SantillanaCentro de Investigaciones Biológicas Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, Spain.
John ZiebuhrInstitute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.ORCID http://orcid.org/0000-0002-5741-8825
Antonio RomeroCentro de Investigaciones Biológicas Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040, Madrid, Spain.ORCID http://orcid.org/0000-0002-6990-6973
Collin ZimmerInstitute of Pharmaceutical and BiomedicalSciences, Johannes Gutenberg-University Mainz, Staudinger Weg 5, 55128, Mainz, Germany.
Annabelle WeldertInstitute of Pharmaceutical and BiomedicalSciences, Johannes Gutenberg-University Mainz, Staudinger Weg 5, 55128, Mainz, Germany.ORCID http://orcid.org/0009-0001-5016-0286
Robert ZimmermannInstitute of Pharmaceutical and BiomedicalSciences, Johannes Gutenberg-University Mainz, Staudinger Weg 5, 55128, Mainz, Germany.
Alessio LodolaDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy.ORCID http://orcid.org/0000-0002-8675-1002
Katarzyna ŚwiderekDepartament de Química Física i Analítica, Universitat Jaume I, 12071, Castelló, Spain.ORCID http://orcid.org/0000-0002-7528-1551
Vicent MolinerDepartament de Química Física i Analítica, Universitat Jaume I, 12071, Castelló, Spain. moliner@uji.es.ORCID http://orcid.org/0000-0002-3665-3391
Florenci V GonzálezDepartament de Química Inorgànica i Orgànica, Universitat Jaume I, 12071, Castelló, Spain. fgonzale@uji.es.ORCID http://orcid.org/0000-0001-5709-734X

Funding

Fundación General CSIC (Fundación General Consejo Superior de Investigaciones Científicas) PIE-202020E224Generalitat Valenciana (Regional Government of Valencia) IDIFEDER/2021/02Generalitat Valenciana (Regional Government of Valencia) SEJI/2020/007Universitat Jaume I (Universitat Jaume I de Castelló) UJI-B2020-03
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (M

Identifiers

PMID38238420
PMCPMC10796436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.