Evidence map›Paper›PMID 38238342›Full record

ArticleScientific data2024

Dataset of human-single neuron activity during a Sternberg working memory task.

Michael Kyzar, Jan Kamiński, Aneta Brzezicka, Chrystal M Reed, Jeffrey M Chung, Adam N Mamelak, Ueli Rutishauser

Abstract readDataset
In one paragraph

Article in Scientific data, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Concept Cells and the Neural Bases of Human Memory.Acta physiologica (Oxford, England) · 2026
    Review
  2. Article
  3. Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael KyzarDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0004-4392-9933
Jan KamińskiDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aneta BrzezickaInstitute of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland.
Chrystal M ReedDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jeffrey M ChungDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Adam N MamelakDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ueli RutishauserDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. rutishauseru@csmc.edu.ORCID 0000-0002-9207-7069

Funding

Neuronal mechanisms of human episodic memoryU01NS117839 · NINDS · CEDARS-SINAI MEDICAL CENTER · PI MAMELAK, ADAM NATHANIEL, RUTISHAUSER, UELI · 2020 to 2024
$7.8M
Invasive Approach to Model Human Cortex-Basal Ganglia Action-Regulating NetworksU01NS098961 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI POURATIAN, NADER · 2016 to 2018
$3.9M
Single-neuron mechanisms of executive control of long-term memory processes in humansR01MH110831 · NIMH · CEDARS-SINAI MEDICAL CENTER · PI RUTISHAUSER, UELI · 2016 to 2020
$2.2M
NIMH NIH HHS R01 MH110831NINDS NIH HHS U01 NS098961NINDS NIH HHS U01 NS117839
6 · The paper itself

Abstract

We present a dataset of 1809 single neurons recorded from the human medial temporal lobe (amygdala and hippocampus) and medial frontal lobe (anterior cingulate cortex, pre-supplementary motor area, ventral medial prefrontal cortex) across 41 sessions from 21 patients that underwent seizure monitoring with depth electrodes. Subjects performed a screening task (907 neurons) to identify images for which highly selective cells were present. Subjects then performed a working memory task (902 neurons), in which they were sequentially presented with 1-3 images for which highly selective cells were present and, following a maintenance period, were asked if the probe was identical to one of the maintained images. This Neurodata Without Borders formatted dataset includes spike times, extracellular spike waveforms, stimuli presented, behavior, electrode locations, and subject demographics. As validation, we replicate previous findings on the selectivity of concept cells and their persistent activity during working memory maintenance. This large dataset of rare human single-neuron recordings and behavior enables the investigation of the neural mechanisms of working memory in humans.

Indexed as

Memory, Short-TermMotor CortexAmygdalaHumansNeuronsTemporal Lobe

Identifiers

PMID38238342
PMCPMC10796636

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.