Evidence map›Paper›PMID 38238036›Full record

ArticleJournal of psychiatry & neuroscience : JPN

State- and trait-related dysfunctions in bipolar disorder across different mood states: a graph theory study.

Yifan Chen, Pengfei Zhao, Chunyu Pan, Miao Chang, Xizhe Zhang, Jia Duan, Yange Wei, Yanqing Tang, Fei Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yifan Chen *From the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang).
Pengfei Zhao *From the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang).
Chunyu PanFrom the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang).
Miao ChangFrom the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang).
Xizhe ZhangFrom the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang).
Jia DuanFrom the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang).
Yange WeiFrom the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang).
Yanqing TangFrom the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang) fei.wang@cmu.edu.cn fei.wang@yale.edu yanqingtang@163.com.
Fei WangFrom the Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chen, Wang); the Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, China (Chen, Zhao, Pan, Duan, Wang); the Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China (Chen, Zhao, Duan, Wei, Wang); the Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China (Chang); the School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China (Zhang); the School of Computer Science and Engineering, Northeastern University, Shenyang, China (Pan); and the Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China (Tang) fei.wang@cmu.edu.cn fei.wang@yale.edu yanqingtang@163.com.
China Medical University · CNNanjing Medical University · CNNanjing Brain Hospital · CNFirst Hospital of China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interplay between state- and trait-related disruptions in structural networks remains unclear in bipolar disorder (BD), but graph theory can offer insights into global and local network changes. We sought to use diffusion-tensor imaging (DTI) and graph theory approaches to analyze structural topological properties across distinct mood states and identify high-risk individuals by examining state- and trait-related impairments in BD.

methodsWe studied changes in white matter network among patients with BD and healthy controls, exploring relationships with clinical variables. Secondary analysis involved comparing patients with BD with unaffected people at high genetic risk for BD.

resultsWe included 152 patients with BD, including 52 with depressive BD (DBD), 64 with euthymic BD (EBD) and 36 with manic BD (MBD); we also included 75 healthy controls. Secondary analyses involved 27 unaffected people at high genetic risk for BD. Patients with DBD and MBD exhibited significantly lower global efficiencies than those with EBD and healthy controls, with patients with DBD showing the lowest global efficiencies. In addition, patients with DBD displayed impaired local efficiency and normalized clustering coefficient (γ). At a global level, γ correlated negatively with depression and anxiety. Compared with healthy controls, and across mood states, patients with BD showed abnormal shortest path lengths in the frontolimbic circuit, a trend mirrored among those at high genetic risk for BD. LIMITATIONS: Considerations include medication effects, absence of recorded BD episode counts and the cross-sectional nature of the study.

conclusionMood-specific whole-brain network metrics could serve as potential biomarkers in BD for transitions between mood states. Moreover, these findings contribute to evidence of trait-related frontolimbic circuit irregularities, shedding light on underlying pathophysiological mechanisms in BD.

Indexed as

Bipolar DisorderWhite MatterBrainCross-Sectional StudiesDiffusion Tensor ImagingHumansMagnetic Resonance Imaging

Identifiers

PMID38238036
PMCPMC10803102
OpenAlexW4390974181

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.