Evidence map›Paper›PMID 38237728›Full record

ArticleThe Journal of investigative dermatology2024

AP-2α/AP-2β Transcription Factors Are Key Regulators of Epidermal Homeostasis.

Hui Zhang, Jackelyn R Raymundo, Kathleen E Daly, Wenjuan Zhu, Bill Senapati, Hanyu Zhong, Arjun R Ahilan, Alexander G Marneros

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hui ZhangCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Jackelyn R RaymundoCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Kathleen E DalyCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Wenjuan ZhuStanford Cardiovascular Institute, Stanford Univeristy, Stanford, California, USA.
Bill SenapatiCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Hanyu ZhongCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Arjun R AhilanCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Alexander G MarnerosCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. Electronic address: amarneros@mgh.harvard.edu.
Harvard University · USCardiovascular Institute of the South · US

Funding

Cellular and molecular mechanisms of AIM2 and NLRP3 inflammasome activation in age-related macular degenerationR01EY033709 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI Alexander Georg Marneros · 2023 to 2026
$2.0M
Molecular mechanisms of choroidal neovascularization and vascular homeostasisR01EY019297 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI MARNEROS, ALEXANDER GEORG · 2008 to 2011
$1.9M
Functional characterization of a novel key regulator of the distal nephron whose deficiency leads to renal fibrosis and cyst formationR01DK118134 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MARNEROS, ALEXANDER GEORG · 2019 to 2023
$1.7M
Proangiogenic M2-type macrophages and choroidal neovascularizationR01EY033360 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI Alexander Georg Marneros · 2022 to 2026
$1.7M
Mechanisms controlling distal nephron maturationR01DK121178 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MARNEROS, ALEXANDER GEORG · 2019 to 2022
$1.4M
Role of KCTD1 for primary hyperparathyroidismR21AG063377 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI MARNEROS, ALEXANDER GEORG · 2019 to 2020
$436k
NEI NIH HHS R01 EY019297NEI NIH HHS R01 EY033360NEI NIH HHS R01 EY033709NIA NIH HHS R21 AG063377NIDDK NIH HHS R01 DK118134NIDDK NIH HHS R01 DK121178
6 · The paper itself

Abstract

AP-2 transcription factors regulate ectodermal development, but their roles in epidermal homeostasis in adult skin are unknown. We find that AP-2α is the predominant AP-2 family member in adult epidermis, followed by AP-2β. Through inactivation of AP-2α, AP-2β, or both in keratinocytes, we assessed the effects of a gradient of epidermal AP-2 activity on skin function. We find that (i) loss of AP-2β in keratinocytes is compensated for by AP-2α, (ii) loss of AP-2α impairs terminal keratinocyte differentiation and hair morphogenesis, and (iii) the combined loss of AP-2α/AP-2β results in more severe skin and hair abnormalities. Keratinocyte differentiation defects precede progressive neutrophilic skin inflammation. Inducible inactivation of AP-2α/AP-2β in the adult phenocopies these manifestations. Transcriptomic analyses of epidermis lacking AP-2α or AP-2α/AP-2β in keratinocytes demonstrate a terminal keratinocyte differentiation defect with upregulation of alarmin keratins and of several immune pathway regulators. Moreover, our analyses suggest a key role of reduced AP-2α-dependent gene expression of CXCL14 and the keratin 15 gene K15 as an early pathogenic event toward the manifestation of skin inflammation. Thus, AP-2α and AP-2β are critical regulators of epidermal homeostasis in adult skin.

Indexed as

Cell DifferentiationEpidermisHomeostasisKeratinocytesTranscription Factor AP-2AnimalsCells, CulturedHumansMiceMice, KnockoutTFAP2A protein, humanTFAP2B protein, humanTranscription Factor AP-2AP-2Atopic dermatitisHair morphogenesisPsoriasisSkin inflammation

Identifiers

PMID38237728
PMCPMC11193656
OpenAlexW4391036008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.