Evidence map›Paper›PMID 38237058›Full record

ArticleACS nano2024

Surface Cross-Linking by Macromolecular Tethers Enhances Virus-like Particles' Resilience to Mucosal Stress Factors.

Ahmed Ali, Suwannee Ganguillet, Yagmur Turgay, Timothy G Keys, Erika Causa, Ricardo Fradique, Viviane Lutz-Bueno, Serge Chesnov, Chia-Wei Tan-Lin, Verena Lentsch and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Colloidal Crystallization of Virus-Like Particles with Polycations.Small (Weinheim an der Bergstrasse, Germany) · 2025
    Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Ahmed AliDepartment of Health Sciences and Technology, ETH Zürich, Zürich 8092, Switzerland.
Suwannee GanguilletDepartment of Health Sciences and Technology, ETH Zürich, Zürich 8092, Switzerland.
Yagmur TurgayDepartment of Health Sciences and Technology, ETH Zürich, Zürich 8092, Switzerland.ORCID 0000-0002-9889-0181
Timothy G KeysDepartment of Health Sciences and Technology, ETH Zürich, Zürich 8092, Switzerland.
Erika CausaBiological and Soft Systems, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, U.K.
Ricardo FradiqueBiological and Soft Systems, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, U.K.
Viviane Lutz-BuenoPaul Scherrer Institute (PSI), Villigen 5232, Switzerland.ORCID 0000-0001-9735-5470
Serge ChesnovFunctional Genomics Centre Zürich (FGCZ), University of Zürich/ETH Zürich, Zürich 8057, Switzerland.
Chia-Wei Tan-LinFunctional Genomics Centre Zürich (FGCZ), University of Zürich/ETH Zürich, Zürich 8057, Switzerland.ORCID 0000-0003-4777-2916
Verena LentschDepartment of Health Sciences and Technology, ETH Zürich, Zürich 8092, Switzerland.
Jurij KotarBiological and Soft Systems, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, U.K.
Pietro CicutaBiological and Soft Systems, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, U.K.ORCID 0000-0002-9193-8496
Raffaele MezzengaDepartment of Health Sciences and Technology, ETH Zürich, Zürich 8092, Switzerland.ORCID 0000-0002-5739-2610
Emma SlackDepartment of Health Sciences and Technology, ETH Zürich, Zürich 8092, Switzerland.
Milad RadiomDepartment of Health Sciences and Technology, ETH Zürich, Zürich 8092, Switzerland.ORCID 0000-0002-6339-9288
ETH Zurich · CHUniversity of Cambridge · GBUniversity of Zurich · CHCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus-like particles (VLPs) are emerging as nanoscaffolds in a variety of biomedical applications including delivery of vaccine antigens and cargo such as mRNA to mucosal surfaces. These soft, colloidal, and proteinaceous structures (capsids) are nevertheless susceptible to mucosal environmental stress factors. We cross-linked multiple capsid surface amino acid residues using homobifunctional polyethylene glycol tethers to improve the persistence and survival of the capsid to model mucosal stressors. Surface cross-linking enhanced the stability of VLPs assembled from

Indexed as

Resilience, PsychologicalVaccines, Virus-Like ParticleAnimalsCapsidCapsid ProteinsHumansMiceSwineCapsid ProteinsVaccines, Virus-Like Particlebiomedical applicationsmucosal deliverymucus interactionsnanoindentationpolyethylene glycol tethersvirus-like particle vaccines

Identifiers

PMID38237058
PMCPMC10832050
OpenAlexW4390966024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.