ArticleMMWR. Morbidity and mortality weekly report2024
Detecting Mpox Cases Through Wastewater Surveillance - United States, August 2022-May 2023.
Article in MMWR. Morbidity and mortality weekly report, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Wastewater Surveillance to Track Resurgent Measles Outbreak, Ontario, Canada, 2025.Emerging infectious diseases · 2026Article
- Monkeypox Virus Surveillance in Wastewater, North Carolina, USA, October 2023-May 2025.Emerging infectious diseases · 2026Article
- Progress and Expansion of the National Wastewater Surveillance System, United States, 2020-2024.Emerging infectious diseases · 2026Article
- Toward a quality-managed operational architecture for wastewater surveillance of zoonotic and emerging pathogens.Applied and environmental microbiology · 2026Review
- From clinical fluids to environmental matrices: quantitative monitoring of infectious monkeypox virus based on PMA-qPCR during the Guangdong outbreak.Tropical medicine and health · 2026Article
- Genetic insights into hepatitis E virus through environmental surveillance in Europe.One health (Amsterdam, Netherlands) · 2026Review
- An integrated framework for early detection and transmissibility assessment of emerging variants in wastewater.International journal of hygiene and environmental health · 2026Article
- Article
- Qualitative assessment of a novel results-based partnership between national wastewater surveillance centers of excellence and utility companies, Houston (Texas), Colorado, Wisconsin, and California, 2023.BMC public health · 2026Article
- Assessing the sensitivity and predictive value of wastewater in detection of Hepatitis A cases in San Diego County.PloS one · 2026Article
- Review
- Molecular Surveillance and Genotypic Distribution of Rotavirus A, Norovirus GI and GII in Bangkok Wastewater Treatment Plants During COVID-19 Phase in 2023, Thailand.Food and environmental virology · 2025Article
- Wastewater Metavirome Diversity: Exploring Replicate Inconsistencies and Bioinformatic Tool Disparities.International journal of environmental research and public health · 2025Article
- Is Southeast Asia and the Western Pacific ready for potential monkeypox virus outbreaks?The Lancet regional health. Western Pacific · 2025Review
- Suspected Mpox Symptoms and Testing in Men Who Have Sex With Men in the United States: Cross-Sectional Study.JMIR public health and surveillance · 2025Article
- Surveillance of Emerging Rodent-Borne Pathogens in Wastewater in Taiwan: A One Health Approach.Tropical medicine and infectious disease · 2024Article
- Wastewater Surveillance of Mpox during the Summer Season of 2023 in Slovenia.Infectious disease reports · 2024Article
- Pathogen prioritisation for wastewater surveillance ahead of the Paris 2024 Olympic and Paralympic Games, France.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In October 2022, CDC's National Wastewater Surveillance System began routine testing of U.S. wastewater for Monkeypox virus. Wastewater surveillance sensitivity, positive predictive value (PPV), and negative predictive value (NPV) for Monkeypox virus were evaluated by comparing wastewater detections (Monkeypox virus detected versus not detected) to numbers of persons with mpox in a county who were shedding virus. Case ascertainment was assumed to be complete, and persons with mpox were assumed to shed virus for 25 days after symptom onset. A total of 281 cases and 3,492 wastewater samples from 89 sites in 26 counties were included in the analysis. Wastewater surveillance in a single week, from samples representing thousands to millions of persons, had a sensitivity of 32% for detecting one or more persons shedding Monkeypox virus, 49% for detecting five or more persons shedding virus, and 77% for detecting 15 or more persons shedding virus. Weekly PPV and NPV for detecting persons shedding Monkeypox virus in a county were 62% and 80%, respectively. An absence of detections in counties with wastewater surveillance signified a high probability that a large number of cases were not present. Results can help to guide the public health response to Monkeypox virus wastewater detections. A single, isolated detection likely warrants a limited public health response. An absence of detections, in combination with no reported cases, can give public health officials greater confidence that no cases are present. Wastewater surveillance can serve as a useful complement to case surveillance for guiding the public health response to an mpox outbreak.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.