Evidence map›Paper›PMID 38236400›Full record

ArticleBrain structure & function2024

Amygdala structure and function and its associations with social-emotional outcomes in a low-risk preterm sample.

L Fernández de Gamarra-Oca, O Lucas-Jiménez, J M Ontañón, B Loureiro-Gonzalez, J Peña, N Ibarretxe-Bilbao, M A García-Guerrero, N Ojeda, L Zubiaurre-Elorza

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Article in Brain structure & function, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L Fernández de Gamarra-OcaDepartment of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Bizkaia, Spain.
O Lucas-JiménezDepartment of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Bizkaia, Spain.
J M OntañónOSATEK, MR Unit, Galdakao Hospital, Galdakao, Spain.
B Loureiro-GonzalezDivision of Neonatology, Biocruces Health Research Institute, Cruces University Hospital, Barakaldo, Bizkaia, Spain.
J PeñaDepartment of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Bizkaia, Spain.
N Ibarretxe-BilbaoDepartment of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Bizkaia, Spain.
M A García-GuerreroDepartment of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Bizkaia, Spain.
N Ojeda *Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Bizkaia, Spain.
L Zubiaurre-Elorza *Department of Psychology, Faculty of Health Sciences, University of Deusto, Bilbao, Bizkaia, Spain. leire.zubiaurre@deusto.es.

Funding

Department of Education and Science of the Basque Government IT1545-22Department of Education of the Basque Government PRE_2019_1_0105Spanish Ministry of Science, Innovation and Universities PSI2017-83657-P
6 · The paper itself

Abstract

Amygdala atypical volume development and functional connectivity (FC) at small gestational ages (GA) have been found across childhood. This adult-oriented study assesses whether altered amygdala structure and function is present following low-risk preterm birth. T1-weighted and resting-state functional MRI images of 33 low-risk preterm (30-36 weeks' GA) and 29 full-term (37-42 weeks' GA) young adults of both sexes, aged between 20 and 32 years old, were analyzed using FreeSurfer (v6.0.0) and Coon Toolbox (v21.a). The social-emotional assessment included Happé's Strange Stories Test, the Moral Judgment Test, Delay-Discounting Test, Adult Self Report, and Emotion Regulation Questionnaire. No differences were found in social-emotional outcomes or amygdala volumes between the groups. Low-risk preterm young adults showed increased FC between the left amygdala, right amygdala and medial frontal cortex (MedFC) (F = 9.89, p-FWE = 0.009) at cluster level compared to their full-term peers. However, significant results at connection level were not observed between left and right amygdala. Lastly, increased FC at cluster level between the right amygdala and MedFC, and left amygdala and MedFC, was related to better social-emotional outcomes only in low-risk preterm young adults (F = 6.60, p-FWE = 0.036) at cluster level. At connection level, in contrast, only right amygdala-MedFC increased FC was significantly associated with better social-emotional outcomes. This study reveals that low-risk prematurity does not have an effect on social-emotional outcomes or structural amygdala volumes during young adulthood. However, individuals who were considered to be at a lower risk of exhibiting neurodevelopmental alterations following preterm birth demonstrated increased FC between the left and right amygdala and MedFC.

Indexed as

Premature BirthAdultAmygdalaChildEmotionsFemaleHumansInfant, NewbornInfant, PrematureMagnetic Resonance ImagingMaleYoung AdultAmygdalaFunctional connectivityLow-risk preterm birthSocial-emotional outcomesYoung adulthood

Identifiers

PMID38236400
PMCPMC10917835

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.