Evidence map›Paper›PMID 38236380›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2024

Unveiling the bioactive potential of Actinomycetota from the Tagus River estuary.

José Diogo Neves Dos Santos, Eugénia Pinto, Jesús Martín, Francisca Vicente, Fernando Reyes, Olga Maria Lage

Abstract read
In one paragraph

Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

José Diogo Neves Dos SantosDepartment of Biology, Faculty of Sciences, University of Porto, Rua Do Campo Alegre, S/N, 4169-007, Porto, Portugal. zesantox@gmail.com.ORCID http://orcid.org/0000-0002-9693-4857
Eugénia PintoInterdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros Do Porto de Leixões, University of Porto, Avenida General Norton de Matos, S/N, 4450-208, Matosinhos, Portugal.ORCID http://orcid.org/0000-0003-2948-5809
Jesús MartínCentro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Fundación MEDINA, Avenida del Conocimiento, 34 Parque Tecnológico de Ciencias de La Salud, 18016, Granada, Spain.
Francisca VicenteCentro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Fundación MEDINA, Avenida del Conocimiento, 34 Parque Tecnológico de Ciencias de La Salud, 18016, Granada, Spain.ORCID http://orcid.org/0000-0003-3198-9205
Fernando ReyesCentro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Fundación MEDINA, Avenida del Conocimiento, 34 Parque Tecnológico de Ciencias de La Salud, 18016, Granada, Spain.ORCID http://orcid.org/0000-0003-1607-5106
Olga Maria LageDepartment of Biology, Faculty of Sciences, University of Porto, Rua Do Campo Alegre, S/N, 4169-007, Porto, Portugal.ORCID http://orcid.org/0000-0002-3950-3970

Funding

Fundação para a Ciência e a Tecnologia SFRH/BD/145576/2019Fundação para a Ciência e a Tecnologia UIDP/04423/2020
6 · The paper itself

Abstract

The increase in global travel and the incorrect and excessive use of antibiotics has led to an unprecedented rise in antibiotic resistance in bacterial and fungal populations. To overcome these problems, novel bioactive natural products must be discovered, which may be found in underexplored environments, such as estuarine habitats. In the present work, estuarine actinomycetotal strains were isolated with conventional and iChip techniques from the Tagus estuary in Alcochete, Portugal, and analysed for different antimicrobial bioactivities. Extracts were produced from the isolated cultures and tested for bioactivity against Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Aspergillus fumigatus ATCC 240305, Candida albicans ATCC 10231 and Trichophyton rubrum FF5. Furthermore, bioactive extracts were subjected to dereplication by high-performance liquid chromatography (HPLC) and high-resolution mass spectrometry (HRMS) to putatively identify their chemical components. In total, 105 isolates belonging to 3 genera were obtained. One which was isolated, MTZ3.1

Indexed as

EstuariesMicrobial Sensitivity TestsRiversAnti-Bacterial AgentsAnti-Infective AgentsBacteriaBiological ProductsCandida albicansEscherichia coliFungiPortugalStaphylococcus aureusAnti-Bacterial AgentsAnti-Infective AgentsBiological ProductsAntimicrobial activitiesHPLC/HRMSiChipMarine ActinomycetotaNovel Actinomycetota

Identifiers

PMID38236380
PMCPMC11452475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.