Evidence map›Paper›PMID 38235933›Full record

ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2024

Dermoscopy and reflectance confocal microscopy finding of different anatomic sites of Langerhans cell histiocytosis.

Gaolei Zhang, Xingjia Wang, Yuhan Wang, Qian Li, Sheng Zhang, Lixiao Jiang, Wei Deng, Xiaoyan Liu, Jianhua Wang

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Dermoscopy and reflectance confocal microscopy finding of different anatomic sites of Langerhans cell histiocytosis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gaolei ZhangDepartment of Dermatology and Venereology, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-4451-7864
Xingjia WangDepartment of Dermatology and Venereology, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing, China.
Yuhan WangDepartment of Dermatology and Venereology, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing, China.
Qian LiDepartment of Dermatology and Venereology, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing, China.
Sheng ZhangDepartment of Dermatology and Venereology, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing, China.
Lixiao JiangDepartment of Dermatology and Venereology, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing, China.
Wei DengDepartment of Dermatology and Venereology, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing, China.
Xiaoyan LiuDepartment of Dermatology and Venereology, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing, China.
Jianhua WangBeijing Municipal Key Laboratory of Child Development and Nutriomics, Translational Medicine Laboratory, Capital Institute of Pediatrics, Beijing, China.
Peking University · CNCapital Institute of Pediatrics · CN

Funding

National Natural Science Foundation of China 81974473National Natural Science Foundation of China 82073461Research Foundation of Capital Institute of Pediatrics JHYJ-2023-06
6 · The paper itself

Abstract

backgroundRecognizing Langerhans cell histiocytosis (LCH) might be a challenge due to its rarity. Reflectance confocal microscopy (RCM) and dermoscopy were emergent promising non-invasive technique as auxiliary tools in diagnosis of different skin conditions. However, the RCM and dermoscopic features of LCH had been less investigated. To reveal the common RCM and dermoscopic features of LCH. MATERIALS AND

methodsForty cases of LCH were retrospectively analyzed according to age, locations, clinical, RCM, and dermoscopic features from September 2016 to December 2022. To reveal the differences and common in clinical, RCM, and dermoscopic features that occur in different anatomic location.

resultsIn the study, sites of predilection include the trunk 31/40 (77.5%), extremity 21/40 (52.5%), face 14/40 (35%), scalp 11/40 (27.5%), vulvar 4/40 (10%), and nail 2/40 (5%). All LCHs had the common RCM features. There were significant differences in clinical and dermoscopic features for age and lesion anatomic site. The common dermoscopic features for scalp, face, trunk, and extremity were the erythematous scaly rash, purplish-red globules or patches, scar-like streaks with ectatic vessels. While the features for nail LCH were purpuric striae, onycholysis and purulent scaly rash, and the erosive erythematous plaque and purulent scaly rash for vulvar LCH. The common RCM features of all LCH showed a focal highly reflective dense image in the surface keratin layer, epidermis architectural disarray, obscuration of dermo-epidermal junction, numerous polygonal, large, medium reflective, short dendrites cells in the epidermis, and dermis. All LCH involving the vulvar and nail did not manifest skin lesions.

conclusionRCM and dermoscopy showed promising value for diagnosis and differentiation of LCH.

Indexed as

ExanthemaMelanomaSkin NeoplasmsDermoscopyDiagnosis, DifferentialHumansMicroscopy, ConfocalRetrospective Studiesanatomic locationdermoscopyhistopathologyLangerhans cell histiocytosisreflectance confocal microscopy

Identifiers

PMID38235933
PMCPMC10795093
OpenAlexW4390974897

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.