Evidence map›Paper›PMID 38235932›Full record

ArticleEuropean journal of neurology2024

Magnetic resonance neurography in spinal cord injury: Imaging findings and clinical significance.

Johann M E Jende, Laura Heutehaus, Fabian Preisner, Christina M Verez Sola, Christoph M Mooshage, Sabine Heiland, Rüdiger Rupp, Martin Bendszus, Norbert Weidner, Felix T Kurz and 1 more

Open access · goldAbstract read
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Johann M E JendeDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-1387-9304
Laura HeutehausSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.
Fabian PreisnerDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Christina M Verez SolaSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.
Christoph M MooshageDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Sabine HeilandDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Rüdiger RuppSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.
Martin BendszusDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Norbert WeidnerSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.
Felix T KurzDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Steffen FranzSpinal Cord Injury Center, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-7707-2497
Heidelberg University · DEGerman Cancer Research Center · DE

Funding

Deutsche Forschungsgemeinschaft SFB1158Else Kröner-Fresenius-Stiftung 2021_EKES.29International Foundation for Research in Paraplegia P179
6 · The paper itself

Abstract

background and purposeIt is unknown whether changes to the peripheral nervous system following spinal cord injury (SCI) are relevant for functional recovery or the development of neuropathic pain below the level of injury. Magnetic resonance neurography (MRN) at 3 T allows detection and localization of structural and functional nerve damage. This study aimed to combine MRN and clinical assessments in individuals with chronic SCI and nondisabled controls.

methodsTwenty participants with chronic SCI and 20 controls matched for gender, age, and body mass index underwent MRN of the L5 dorsal root ganglia (DRG) and the sciatic nerve. DRG volume, sciatic nerve mean cross-sectional area (CSA), fascicular lesion load, and fractional anisotropy (FA), a marker for functional nerve integrity, were calculated. Results were correlated with clinical assessments and nerve conduction studies.

resultsSciatic nerve CSA and lesion load were higher (21.29 ± 5.82 mm

conclusionsIndividuals with chronic SCI are subject to a decline of structural peripheral nerve integrity that may occur independently from the clinical severity of SCI. Larger volumes of DRG in SCI with neuropathic pain support existing evidence from animal studies on SCI-related neuropathic pain.

Indexed as

NeuralgiaSpinal Cord InjuriesAnimalsClinical RelevanceHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopySciatic NerveSpinal Cordbelow-level painmagnetic resonance neurographyneuropathic painperipheral nervous systemspinal cord injury

Identifiers

PMID38235932
PMCPMC11235803
OpenAlexW4390985249

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.