Evidence map›Paper›PMID 38235411›Full record

ArticleBrain, behavior, & immunity - health2024

Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents.

Saché M Coury, Vanessa López, Zia Bajwa, Jordan M Garcia, Giana I Teresi, Kate R Kuhlman, Yan Li, Steve Cole, David J Miklowitz, Ioannis Pappas and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05329441 (Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05329441 recruitingnot on this map

Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression: Toward Predictors of Treatment Response and Clinical Course

TypeobservationalSponsorUniversity of California, Los AngelesRan2023 to 2028Enrolled160ConditionsDepression in AdolescenceArmsTrier Social Stress Test (TSST)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Saché M CouryDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Vanessa LópezDepartment of Neuroscience, Columbia University, New York, NY, USA.
Zia BajwaDepartment of Psychiatry, Columnia University, New York, NY, USA.
Jordan M GarciaSchool of Social Work, University of Washington, Seattle, WA, USA.
Giana I TeresiDepartment of Psychology, University of Pittsburgh, Pittsburgh, USA.
Kate R KuhlmanDepartment of Psychological Science, School of Social Ecology, University of California Irvine, Irvine, CA, USA.
Yan LiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Steve ColeCousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA.
David J MiklowitzDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Ioannis PappasLaboratory of NeuroImaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tiffany C HoDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USColumbia University · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USUniversity of Southern California · USUniversity of Washington · US

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2020 to 2026
$27.8M
Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents with Depression: Toward Predictors of Treatment Response and Clinical CourseR01MH127176 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TIFFANY CHEING HO · 2022 to 2026
$3.1M
The Roles of Inflammatory and Glutamatergic Processes in the Neurodevelopmental Mechanisms Underlying Adolescent DepressionK01MH117442 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HO, TIFFANY CHEING · 2018 to 2022
$881k
NIA NIH HHS P30 AG066530NIMH NIH HHS K01 MH117442NIMH NIH HHS R01 MH127176
6 · The paper itself

Abstract

Adolescent-onset depression is a prevalent and debilitating condition commonly associated with treatment refractory depression and non-response to first-line antidepressants. There are, however, no objective tests to determine who may or may not respond to antidepressants. As depressed adolescents are especially vulnerable to the lifelong consequences of ineffectively-treated depression, it is critical to identify neurobiological predictors of treatment non-response in this population. Here, we describe the scientific rationale and protocol for the Teen Inflammation Glutamate Emotion Research (TIGER) study, a prospective 18-month investigation of 160 depressed adolescents who will be assessed before and after treatment with selective serotonin reuptake inhibitors. TIGER will be using ultra-high field imaging to test the effects of acute stress and antidepressant treatment on inflammatory and glutamatergic processes hypothesized to underlie depression maintenance. Results from this work will motivate future studies testing alternative therapeutics for depressed adolescents at risk for treatment resistant depression. ClinicalTrials.gov Identifier: NCT05329441.

Indexed as

AdolescenceDepressionFronto-cingulate-limbic circuitsMagnetic resonance spectroscopySelective serotonin reuptake inhibitorsSocial stress

Identifiers

PMID38235411
PMCPMC10792689
OpenAlexW4390033448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.