ReviewFrontiers in physiology2023
Beyond protein synthesis: the emerging role of arginine in poultry nutrition and host-microbe interactions.
Review in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.Gut microbes · 2026Review
- CPS1: a multipurpose mitochondrial enzyme, bile protein, acute liver injury biomarker, and cytokine.Gut · 2026Review
- Effects of dietary threonine and arginine on growth performance, stress indicators, and gut health in broiler chickens under multiple stress.Journal of animal science and technology · 2026Article
- Integrated multi-omics analysis reveals breed-specific molecular and metabolic architectures of breast muscle in Cherry Valley, Muscovy, and mule ducks.Poultry science · 2026Article
- Increasing standardized ileal digestible arginine-to-lysine ratios improves growth performance and carcass characteristics in 10- to 31-d-old broilers.Poultry science · 2026Article
- Comparative study of the role of nitric oxide in the regulation of food intake across vertebrates.Journal of veterinary science · 2026Review
- Steering nitrogen emission from poultry production through precision nutrition.Poultry science · 2026Review
- Effects ofJournal of animal science and technology · 2026Article
- The Effects of L-Citrulline on the Apparent Digestion and Metabolism of Nutrients, Blood Hormone Levels, Amino Acid Metabolism and the Diversity of Faecal Microbiota in Mares in the Later Stage of Pregnancy.Life (Basel, Switzerland) · 2026Article
- Sustainable Rearing ofInsects · 2026Article
- Dietary arginine modulates egg production and mTOR signalling pathway gene expression in adult Japanese quail (Veterinary and animal science · 2026Article
- N-Carbamylglutamate Promotes Growth and Immunity in Danzhou Chickens via Gut Microbiota-Metabolite Interactions Involving Sphingolipid and mTOR Pathways.Microorganisms · 2026Article
- Probiotic-enzyme complex improves laying performance in laying hens fed low-protein diets by modulating gut microbiota and host metabolism.Frontiers in veterinary science · 2026Article
- Gut microbiota L-ornithine promotes resistance to obesity through metabolites mediated immunosuppressive macrophages.Cellular and molecular life sciences : CMLS · 2025Article
- Optimizing low crude protein diet: Evaluating Glycine as a conditionally essential Amino Acid.Poultry science · 2025Review
- L-arginine supplement ameliorates dichlorvos-induced systemic inflammatory response and liver dysfunction in male wistar rats.Toxicology reports · 2025Article
- Assessing the Genetic and Environmental Factors on Egg Amino Acid Traits in Chickens: A Review.Animals : an open access journal from MDPI · 2025Review
- Recent advances in protein and amino acid nutritional dynamics in relation to performance, health, welfare, and cost of production.Poultry science · 2025Review
- Optimization of citrulline production from a Bacillus subtilis BH-01 isolated from raw buffalo milk.BMC microbiology · 2025Article
- Dietary supplementation withFrontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arginine is a functional amino acid essential for various physiological processes in poultry. The dietary essentiality of arginine in poultry stems from the absence of the enzyme carbamoyl phosphate synthase-I. The specific requirement for arginine in poultry varies based on several factors, such as age, dietary factors, and physiological status. Additionally, arginine absorption and utilization are also influenced by the presence of antagonists. However, dietary interventions can mitigate the effect of these factors affecting arginine utilization. In poultry, arginine is utilized by four enzymes, namely, inducible nitric oxide synthase arginase, arginine decarboxylase and arginine: glycine amidinotransferase (AGAT). The intermediates and products of arginine metabolism by these enzymes mediate the different physiological functions of arginine in poultry. The most studied function of arginine in humans, as well as poultry, is its role in immune response. Arginine exerts immunomodulatory functions primarily through the metabolites nitric oxide (NO), ornithine, citrulline, and polyamines, which take part in inflammation or the resolution of inflammation. These properties of arginine and arginine metabolites potentiate its use as a nutraceutical to prevent the incidence of enteric diseases in poultry. Furthermore, arginine is utilized by the poultry gut microbiota, the metabolites of which might have important implications for gut microbial composition, immune regulation, metabolism, and overall host health. This comprehensive review provides insights into the multifaceted roles of arginine and arginine metabolites in poultry nutrition and wellbeing, with particular emphasis on the potential of arginine in immune regulation and microbial homeostasis in poultry.
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