ArticleiScience2024
Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity.
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Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Evaluation of Cellular Immune Responses After mRNA-1273 Vaccination in Children 6 Months to 11 Years of Age.The Journal of infectious diseases · 2025Trial
- Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections.bioRxiv : the preprint server for biology · 2025Article
- Article
- Compartmentalised mucosal and blood immunity to SARS-CoV-2 is associated with high seroprevalence before the Delta wave in Africa.Communications medicine · 2025Article
- Assessing the Value of T cell Monitoring in the General Population of Children and Adolescents - Insights From the Ciao Corona Cohort Study.International journal of public health · 2025Observational
- A 10 Year Long-Lived Cellular and Humoral MERS-CoV Immunity Cross-Recognizing the Wild-Type and Variants of SARS-CoV-2: A Potential One-Way MERS-CoV Cross-Protection Toward a Pan-Coronavirus Vaccine.Journal of medical virology · 2025Article
- What goes up must come down: dynamics of type 1 interferon signaling across the lifespan.Frontiers in immunology · 2025Review
- Editorial: Quantification and prediction of T-cell cross-reactivity through experimental and computational methods.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
31 authors at 8 institutions in 2 countries.
Ntombi BenedeInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Marius B TinchoInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Avril WaltersInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Vennesa SubbiahInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Amkele NgomtiInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Richard BagumaInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Claire ButtersDivision of Paediatric Rheumatology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Observatory, South Africa.
Lina HahnleDepartment of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa.
Mathilda MennenDepartment of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa.
Sango SkelemDepartment of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa.
Marguerite AdriaanseDepartment of Medicine, University of Cape Town and Groote Schuur Hospital, Observatory, South Africa.
Heidi Facey-ThomasDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Christiaan ScottDivision of Paediatric Rheumatology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Observatory, South Africa.
Jonathan DayDivision of Paediatric Rheumatology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Observatory, South Africa.
Timothy F SpracklenDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Strauss van GraanNational Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.
Sashkia R BallaNational Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.
Thandeka Moyo-GweteNational Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.
Penny L MooreInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Rae MacGintyDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Maresa BothaDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Lesley WorkmanDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Marina JohnsonGreat Ormond Street Institute of Child Health Biomedical Research Centre, University College London, London, UK.
David GoldblattGreat Ormond Street Institute of Child Health Biomedical Research Centre, University College London, London, UK.
Heather J ZarInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Ntobeko A B NtusiInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Liesl ZühlkeInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Kate WebbDivision of Paediatric Rheumatology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Observatory, South Africa.
Catherine RiouInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Wendy A BurgersInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
Roanne S KeetonInstitute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.
University of Cape Town · ZAWellcome Centre for Infectious Diseases Research in Africa · ZASouth African Medical Research Council · ZAUniversity College London · GBCentre for the AIDS Programme of Research in South Africa · ZANational Health Laboratory Service · ZAThe Francis Crick Institute · GBUniversity of the Witwatersrand · ZA
Funding
Contribution of the CD153/CD30 axis to Mycobacterium tuberculosis control in humansR21AI148027 · NIAID · UNIVERSITY OF CAPE TOWN · PI RIOU, CATHERINE · 2019 to 2020
$291kNIAID NIH HHS R21 AI148027Wellcome Trust
Abstract
SARS-CoV-2 infection in children typically results in asymptomatic or mild disease. There is a paucity of studies on SARS-CoV-2 antiviral immunity in African children. We investigated SARS-CoV-2-specific T cell responses in 71 unvaccinated asymptomatic South African children who were seropositive or seronegative for SARS-CoV-2. SARS-CoV-2-specific CD4
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Components of the immune systemImmune responseImmunologyVirology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.